Environmental Microbial Genomics

Lars Hestbjerg Hansens Environmental Microbial Genomics group has the expertise to perform genomic and metagenomic studies in a highly customized manner using in-house high-throughput and full genome sequencing (Illumina and Nanopore sequencers) of pro- and eukaryotic organisms.

The group uses sequence-analysis based information to describe genomic traits of keystone species and their prevalence in natural and artificial microbial communities and metagenomes, including information on bacteriophages and how other mobile genetic elements shape microbial evolution and traits. Group activities span microbes in both natural, agricultural and health related systems.

Research themes

Phyllosphere hub species and bacteriophages as biocontrol agents in agriculture
The use of alterative bases in bacteriophage genomes
Manipulating gut microbiomes via FMT or bacteriophage therapy
The genetic origin of antibiotic resistance
Mobility of genetic parasites and their role in shaping bacterial evolution
Microbiomics, mobilomics and viromics
Epigenetics in bacteria and bacteriophages

Current research projects

The MATRIX: Microbiome Assisted Triticum Resilience In X- dimensions”. Novo Nordisk Foundation DKK 62.5 M.
MicroHealth: Fecal MICRObiota transplant technology for human HEALTH”. Innovation Fund Denmark DKK 11.5 M (total 20 M).
New letters to the DNA alphabet: Identification and characterization of novel nucleic acids in bacteriophages. Human Frontier Science Program Grant (DKK 6 M), and Villum Experiment (DKK 2 M).
Searching for epigenetic patterns: Applying and optimizing nanopore-based sequencing technology to detect and describe epigenetic patterns in bacteriophages and bacterial persister cells. Partly financed by a Lundbeck Experiment Grant (DKK 2 M).
AutoPhage: Automation to revolutionize bacteriophage isolation and characterization; a novel project to rapidly lower costs and speed up phage work by employing automation. Funded by an individual FTP Postdoc Grant (DKK 1.4 M).
Bacteriophage biocontrol 1: Using bacteriophages as a green-tech alternative to conventional pesticide treatment.
Bacteriophage biocontrol 2: Application and formulation of bacteriophages for controlling bacterial plant pathogens in agricultural practices.
Mobilome dynamics: Deciphering the dynamics involved in mobilization of antibiotic resistance genes (ARGs) among environmental bacteria in order to predict the potential risk within spread of resistance.
Integrating research and education: Integrating research on genomics of bacterial plant pathogens into the MSc course Applied Microbiology. Funded by a Grant of DKK 50.000

Group members

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Nikoline S. Olsen, PhD student. E-mail: niso@evens.au.dk
Joseph Donald Martins, Phd student. E-mail: jdmar@evns.au.dk
Marie Rønne Aggerbeck, Phd student. E-mail: mrag@envs.au.dk
Ole Hylling, PhD Student. E-mail: ohy@envs.au.dk

Master students

Maja Pløger. E-mail: jrd102@alumni.ku.dk
Katrine Johansen Nielsen. E-mail: wxf419@alumni.ku.dk
Julie Stenberg Pedersen. E-mail: hzf242@alumni.ku.dk
Mikkel Haahr Pedersen. E-mail: mtp241@alumni.ku.dk
Jacob Bruun Jørgensen. E-mail: csp411@alumni.ku.dk
Mie Gylling. E-mail: lfd886@alumni.ku.dk

Contact research group leader

Lars Hestbjerg Hansen
Professor
M: lhha@plen.ku.dk
Ph: +45 28 75 20 53