Acid mine drainage (AMD), a waste product of mining activities containing sulfates, iron and heavy metals, causes severe environmental degradation and pose risks to human health and sustainable development. Areas impacted by AMD are lacking remediation techniques that holistically address the ecologic, social, and economic needs of affected communities, for which phytoremediation is a promising solution. This review article introduces AMD and AMD-impacted environments and critically discusses phytomanagement, phytoprotection, and phytorestoration approaches towards AMD-impacted environments. Continued research and application of such approaches will help optimize resource and revenue-generating potentials, address biodiversity loss and carbon storage concerns of climate change, and promote sustainable agricultural management. With a focus on energy crops, phytomining critical elements, carbon storage, co-cropping, allelopathy, and ecosystem restoration, this review examines phytoremediation research that addresses positive economic and environmental opportunities for AMD-impacted environments.