Find more information about the Non-Coding Transcription research group here
Research Group: Non-coding Transcription
Our lab is interested in the functional consequences of non-coding transcription independent of the lncRNA. We study how the mechanism of transcription of non-coding regions affects nearby gene expression through changes in chromatin packaging and modification. We are pursuing how this dynamic non-coding transcription may be part of plant environmental sensing mechanisms by studying transcription kinetics in environmental interactions.
Only a small proportion of DNA in higher organisms represents genes. Interestingly, most non-coding sequences are actively transcribed to yield long non-coding RNA (lncRNA). Gene promoters represent a conserved source of lncRNA through divergent non-coding transcription. However, the generated lncRNA molecules are not usually conserved, whereas genome-wide non-coding transcription is found in wide range of organisms.
- Epigenetics: We are exploring the effects of chromatin structure on inheritance and functional genomic elements.
- Non-coding DNA: We are testing which of the many DNA sequences in eukaryotic genomes that do not code for proteins (i.e. non-coding DNA) serve a purpose.
- Gene expression: We are characterizing the molecular mechanisms regulation gene expression by RNA polymerase II transcription.
- Genomics: We are developing Next-generation sequencing methods to characterize transcriptional dynamics, gene isoform diversity and chromatin-based genome organization.
- Environmental sensing: We are characterizing how plants adopt to changing temperature at the molecular level to inform novel strategies to combat the effects of climate change.
- Novo Nordisk Foundation Hallas-Møller Investigator Award: This project characterizes the rules and roles of long non-coding RNA.
- European Research Council Starting Grant: This project characterizes the molecular mechanism of gene repression by the act of upstream non-coding transcription in the context of climate change.
- Novo Nordisk Foundation Biotechnology project grant: This project aims to transfer regulation of plant cold tolerance by long non-coding to generate crops with increased resilience to climate change.
- European Molecular Biology Organization Young Investigator Programme: This project supports the characterization of environmental effects on gene expression mediated by non-coding DNA.
Group members
| Navn | Titel | Telefon | |
|---|---|---|---|
| Desire Garcia Pichardo | Adjunkt | +4535327016 | |
| Giorgio Gullotta | Ph.d.-stipendiat | +4535327444 | |
| Karina Chalenko | Ph.d.-stipendiat | +4535331992 | |
| Katerina Adamusová | Postdoc | +4535335655 | |
| María Luz Annacondia López | Postdoc | +4535331082 |
Contact research group leader
Sebastian Marquardt
Associate Professor
M: sebastian.marquardt@plen.ku.dk
Ph: +45 35 33 13 05