Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana
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Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana. / Ziem, J. B.; Spannbrucker, N.; Magnussen, P.; Olsen, A.; Amon-Kotey, D. Nii; Frenzel, K.; Nang-beifubah, A.; Westendorp, R. G.J.; Polderman, A. M.
In: Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 99, No. 6, 01.06.2005, p. 417-422.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Oesophagostomum bifurcum-induced nodular pathology in a highly endemic area of Northern Ghana
AU - Ziem, J. B.
AU - Spannbrucker, N.
AU - Magnussen, P.
AU - Olsen, A.
AU - Amon-Kotey, D. Nii
AU - Frenzel, K.
AU - Nang-beifubah, A.
AU - Westendorp, R. G.J.
AU - Polderman, A. M.
PY - 2005/6/1
Y1 - 2005/6/1
N2 - Human infection with Oesophagostomum bifurcum is rare globally, but focally endemic and common in Ghana and Togo. Two clinical presentations are identified: uni-nodular disease, which may be recognized as a 'Dapaong Tumour', and multi-nodular disease. Here, we describe the prevalence of O. bifurcum infection and the association with nodular pathology in northern Ghana. The study was performed in October 2002. Out of a well-defined population of approximately 18 000, 928 subjects of all ages were randomly selected for parasitological and ultrasound examination. In stool cultures, 44% had detectable third-stage O. bifurcum larvae present. Females were more often infected than males (P < 0.05). In 34% of the samples, nodules were detected along the colon wall, with the ascending and the transverse colon being the most affected regions. Significant correlations existed between the intensity of infection and the presence of nodules, both at the village and the individual level (P < 0.001 for both). Patients with multi-nodular pathology had significantly higher larval counts than patients with uni-nodular pathology. The present data suggest that nodular pathology, and probably the severity of the disease, are directly related to intensity of the infection.
AB - Human infection with Oesophagostomum bifurcum is rare globally, but focally endemic and common in Ghana and Togo. Two clinical presentations are identified: uni-nodular disease, which may be recognized as a 'Dapaong Tumour', and multi-nodular disease. Here, we describe the prevalence of O. bifurcum infection and the association with nodular pathology in northern Ghana. The study was performed in October 2002. Out of a well-defined population of approximately 18 000, 928 subjects of all ages were randomly selected for parasitological and ultrasound examination. In stool cultures, 44% had detectable third-stage O. bifurcum larvae present. Females were more often infected than males (P < 0.05). In 34% of the samples, nodules were detected along the colon wall, with the ascending and the transverse colon being the most affected regions. Significant correlations existed between the intensity of infection and the presence of nodules, both at the village and the individual level (P < 0.001 for both). Patients with multi-nodular pathology had significantly higher larval counts than patients with uni-nodular pathology. The present data suggest that nodular pathology, and probably the severity of the disease, are directly related to intensity of the infection.
KW - Colonic nodules
KW - Coproculture
KW - Ghana
KW - Oesophagostomiasis
KW - Oesophagostomum bifurcum
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=17144423576&partnerID=8YFLogxK
U2 - 10.1016/j.trstmh.2004.07.008
DO - 10.1016/j.trstmh.2004.07.008
M3 - Journal article
C2 - 15837353
AN - SCOPUS:17144423576
VL - 99
SP - 417
EP - 422
JO - Transactions of the Royal Society of Tropical Medicine and Hygiene
JF - Transactions of the Royal Society of Tropical Medicine and Hygiene
SN - 0035-9203
IS - 6
ER -
ID: 224706069