From additivity to synergism: a modelling perspectice
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From additivity to synergism : a modelling perspectice. / Ritz, Christian; Streibig, Jens Carl.
In: Synergy, Vol. 1, No. 1, 2014, p. 22-29.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - From additivity to synergism
T2 - a modelling perspectice
AU - Ritz, Christian
AU - Streibig, Jens Carl
PY - 2014
Y1 - 2014
N2 - Interest in synergistic or antagonistic effects through mixture experiments has grown immensely over the past two decades, not the least within in pharmacology and toxicology. Several definitions of reference models exist; one commonly used reference model is concentration or dose addition, which assumes compounds, when administrated simultaneously, do not interfere with each other at the site of action. We focus on statistical modelling that allows evaluation of dose addition. We will describe several statistical approaches that are suitable for analysis mixture data where synergistic or antagonistic effects may be present. The statistical models are defined and explained and some of the approaches exemplified. Code in open-source software is provided.
AB - Interest in synergistic or antagonistic effects through mixture experiments has grown immensely over the past two decades, not the least within in pharmacology and toxicology. Several definitions of reference models exist; one commonly used reference model is concentration or dose addition, which assumes compounds, when administrated simultaneously, do not interfere with each other at the site of action. We focus on statistical modelling that allows evaluation of dose addition. We will describe several statistical approaches that are suitable for analysis mixture data where synergistic or antagonistic effects may be present. The statistical models are defined and explained and some of the approaches exemplified. Code in open-source software is provided.
U2 - 10.1016/j.synres.2014.07.010
DO - 10.1016/j.synres.2014.07.010
M3 - Journal article
VL - 1
SP - 22
EP - 29
JO - Synergy
JF - Synergy
SN - 0838-0368
IS - 1
ER -
ID: 130248221