Dose-response analysis using R
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Dose-response analysis using R. / Ritz, Christian; Baty, Florent; Streibig, Jens Carl; Gerhard, Daniel.
In: P L o S One, Vol. 10, No. 12, e0146021, 2015.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Dose-response analysis using R
AU - Ritz, Christian
AU - Baty, Florent
AU - Streibig, Jens Carl
AU - Gerhard, Daniel
N1 - CURIS 2015 NEXS 422
PY - 2015
Y1 - 2015
N2 - Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.
AB - Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.
U2 - 10.1371/journal.pone.0146021
DO - 10.1371/journal.pone.0146021
M3 - Journal article
C2 - 26717316
VL - 10
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 12
M1 - e0146021
ER -
ID: 152991807