Adaptation at different points along antibiotic concentration gradients
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Adaptation at different points along antibiotic concentration gradients. / Lagator, Mato; Uecker, Hildegard; Neve, Paul.
In: Biology Letters, Vol. 17, No. 5, 20200913, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adaptation at different points along antibiotic concentration gradients
AU - Lagator, Mato
AU - Uecker, Hildegard
AU - Neve, Paul
PY - 2021
Y1 - 2021
N2 - Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains.
AB - Antibiotic concentrations vary dramatically in the body and the environment. Hence, understanding the dynamics of resistance evolution along antibiotic concentration gradients is critical for predicting and slowing the emergence and spread of resistance. While it has been shown that increasing the concentration of an antibiotic slows resistance evolution, how adaptation to one antibiotic concentration correlates with fitness at other points along the gradient has not received much attention. Here, we selected populations of Escherichia coli at several points along a concentration gradient for three different antibiotics, asking how rapidly resistance evolved and whether populations became specialized to the antibiotic concentration they were selected on. Populations selected at higher concentrations evolved resistance more slowly but exhibited equal or higher fitness across the whole gradient. Populations selected at lower concentrations evolved resistance rapidly, but overall fitness in the presence of antibiotics was lower. However, these populations readily adapted to higher concentrations upon subsequent selection. Our results indicate that resistance management strategies must account not only for the rates of resistance evolution but also for the fitness of evolved strains.
KW - antibiotic resistance
KW - drug dose
KW - adaptation
KW - BENEFICIAL MUTATIONS
KW - HERBICIDE RESISTANCE
KW - ENVIRONMENTAL-CHANGE
KW - EVOLUTIONARY RESCUE
KW - DRUG-RESISTANCE
KW - FITNESS COSTS
KW - SELECTION
KW - POPULATIONS
KW - MECHANISMS
KW - COMPENSATION
U2 - 10.1098/rsbl.2020.0913
DO - 10.1098/rsbl.2020.0913
M3 - Journal article
C2 - 33975485
VL - 17
JO - Biology Letters
JF - Biology Letters
SN - 1744-9561
IS - 5
M1 - 20200913
ER -
ID: 270548760