A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. / Tergemina, Emmanuel; Elfarargi, Ahmed F.; Flis, Paulina; Fulgione, Andrea; Göktay, Mehmet; Neto, Célia; Scholle, Marleen; Flood, Pádraic J.; Xerri, Sophie Asako; Zicola, Johan; Döring, Nina; Dinis, Herculano; Krämer, Ute; Salt, David E.; Hancock, Angela M.

In: Science Advances, Vol. 8, No. 20, eabm9385, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tergemina, E, Elfarargi, AF, Flis, P, Fulgione, A, Göktay, M, Neto, C, Scholle, M, Flood, PJ, Xerri, SA, Zicola, J, Döring, N, Dinis, H, Krämer, U, Salt, DE & Hancock, AM 2022, 'A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment', Science Advances, vol. 8, no. 20, eabm9385. https://doi.org/10.1126/sciadv.abm9385

APA

Tergemina, E., Elfarargi, A. F., Flis, P., Fulgione, A., Göktay, M., Neto, C., Scholle, M., Flood, P. J., Xerri, S. A., Zicola, J., Döring, N., Dinis, H., Krämer, U., Salt, D. E., & Hancock, A. M. (2022). A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. Science Advances, 8(20), [eabm9385]. https://doi.org/10.1126/sciadv.abm9385

Vancouver

Tergemina E, Elfarargi AF, Flis P, Fulgione A, Göktay M, Neto C et al. A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. Science Advances. 2022;8(20). eabm9385. https://doi.org/10.1126/sciadv.abm9385

Author

Tergemina, Emmanuel ; Elfarargi, Ahmed F. ; Flis, Paulina ; Fulgione, Andrea ; Göktay, Mehmet ; Neto, Célia ; Scholle, Marleen ; Flood, Pádraic J. ; Xerri, Sophie Asako ; Zicola, Johan ; Döring, Nina ; Dinis, Herculano ; Krämer, Ute ; Salt, David E. ; Hancock, Angela M. / A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment. In: Science Advances. 2022 ; Vol. 8, No. 20.

Bibtex

@article{677ab5a620a64a6cb23a82e1d6ace62e,
title = "A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment",
abstract = "Most well-characterized cases of adaptation involve single genetic loci. Theory suggests that multilocus adaptive walks should be common, but these are challenging to identify in natural populations. Here, we combine trait mapping with population genetic modeling to show that a two-step process rewired nutrient homeostasis in a population of Arabidopsis as it colonized the base of an active stratovolcano characterized by extremely low soil manganese (Mn). First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves. Second, multiple independent tandem duplications occurred at NRAMP1 and together rose to near fixation in the island population, compensating the loss of IRT1 by improving Fe homeostasis. This study provides a clear case of a multilocus adaptive walk and reveals how genetic variants reshaped a phenotype and spread over space and time.",
author = "Emmanuel Tergemina and Elfarargi, {Ahmed F.} and Paulina Flis and Andrea Fulgione and Mehmet G{\"o}ktay and C{\'e}lia Neto and Marleen Scholle and Flood, {P{\'a}draic J.} and Xerri, {Sophie Asako} and Johan Zicola and Nina D{\"o}ring and Herculano Dinis and Ute Kr{\"a}mer and Salt, {David E.} and Hancock, {Angela M.}",
note = "Publisher Copyright: Copyright {\textcopyright} 2022 The Authors,",
year = "2022",
doi = "10.1126/sciadv.abm9385",
language = "English",
volume = "8",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "20",

}

RIS

TY - JOUR

T1 - A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment

AU - Tergemina, Emmanuel

AU - Elfarargi, Ahmed F.

AU - Flis, Paulina

AU - Fulgione, Andrea

AU - Göktay, Mehmet

AU - Neto, Célia

AU - Scholle, Marleen

AU - Flood, Pádraic J.

AU - Xerri, Sophie Asako

AU - Zicola, Johan

AU - Döring, Nina

AU - Dinis, Herculano

AU - Krämer, Ute

AU - Salt, David E.

AU - Hancock, Angela M.

N1 - Publisher Copyright: Copyright © 2022 The Authors,

PY - 2022

Y1 - 2022

N2 - Most well-characterized cases of adaptation involve single genetic loci. Theory suggests that multilocus adaptive walks should be common, but these are challenging to identify in natural populations. Here, we combine trait mapping with population genetic modeling to show that a two-step process rewired nutrient homeostasis in a population of Arabidopsis as it colonized the base of an active stratovolcano characterized by extremely low soil manganese (Mn). First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves. Second, multiple independent tandem duplications occurred at NRAMP1 and together rose to near fixation in the island population, compensating the loss of IRT1 by improving Fe homeostasis. This study provides a clear case of a multilocus adaptive walk and reveals how genetic variants reshaped a phenotype and spread over space and time.

AB - Most well-characterized cases of adaptation involve single genetic loci. Theory suggests that multilocus adaptive walks should be common, but these are challenging to identify in natural populations. Here, we combine trait mapping with population genetic modeling to show that a two-step process rewired nutrient homeostasis in a population of Arabidopsis as it colonized the base of an active stratovolcano characterized by extremely low soil manganese (Mn). First, a variant that disrupted the primary iron (Fe) uptake transporter gene (IRT1) swept quickly to fixation in a hard selective sweep, increasing Mn but limiting Fe in the leaves. Second, multiple independent tandem duplications occurred at NRAMP1 and together rose to near fixation in the island population, compensating the loss of IRT1 by improving Fe homeostasis. This study provides a clear case of a multilocus adaptive walk and reveals how genetic variants reshaped a phenotype and spread over space and time.

U2 - 10.1126/sciadv.abm9385

DO - 10.1126/sciadv.abm9385

M3 - Journal article

C2 - 35584228

AN - SCOPUS:85130277509

VL - 8

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 20

M1 - eabm9385

ER -

ID: 310144837