Transport engineering in microbial cell factories producing plant-specialized metabolites

Research output: Contribution to journal › Review › Research › peer-review

Standard

Transport engineering in microbial cell factories producing plant-specialized metabolites. / Belew, Zeinu Mussa; Poborsky, Michal; Nour-Eldin, Hussam Hassan; Halkier, Barbara Ann.

In: Current Opinion in Green and Sustainable Chemistry, Vol. 33, 100576, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Belew, ZM, Poborsky, M, Nour-Eldin, HH & Halkier, BA 2022, 'Transport engineering in microbial cell factories producing plant-specialized metabolites', Current Opinion in Green and Sustainable Chemistry, vol. 33, 100576. https://doi.org/10.1016/j.cogsc.2021.100576

APA

Belew, Z. M., Poborsky, M., Nour-Eldin, H. H., & Halkier, B. A. (2022). Transport engineering in microbial cell factories producing plant-specialized metabolites. Current Opinion in Green and Sustainable Chemistry, 33, [100576]. https://doi.org/10.1016/j.cogsc.2021.100576

Vancouver

Belew ZM, Poborsky M, Nour-Eldin HH, Halkier BA. Transport engineering in microbial cell factories producing plant-specialized metabolites. Current Opinion in Green and Sustainable Chemistry. 2022;33. 100576. https://doi.org/10.1016/j.cogsc.2021.100576

Author

Belew, Zeinu Mussa ; Poborsky, Michal ; Nour-Eldin, Hussam Hassan ; Halkier, Barbara Ann. / Transport engineering in microbial cell factories producing plant-specialized metabolites. In: Current Opinion in Green and Sustainable Chemistry. 2022 ; Vol. 33.

Bibtex

@article{044502467b834067a5fe266863f1e2a4,
title = "Transport engineering in microbial cell factories producing plant-specialized metabolites",
abstract = "Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.",
keywords = "Feedback inhibition, Metabolic engineering, Microbial cell factories, Pathway engineering, Plant specialized metabolites, Transport engineering",
author = "Belew, {Zeinu Mussa} and Michal Poborsky and Nour-Eldin, {Hussam Hassan} and Halkier, {Barbara Ann}",
note = "Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",
year = "2022",
doi = "10.1016/j.cogsc.2021.100576",
language = "English",
volume = "33",
journal = "Current Opinion in Green and Sustainable Chemistry",
issn = "2452-2236",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Transport engineering in microbial cell factories producing plant-specialized metabolites

AU - Belew, Zeinu Mussa

AU - Poborsky, Michal

AU - Nour-Eldin, Hussam Hassan

AU - Halkier, Barbara Ann

N1 - Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022

Y1 - 2022

N2 - Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.

AB - Transport engineering strategies use altered expression of transporter proteins to change metabolite distribution within an organism. The production of plant specialized metabolites in microbial cell factories encounters a set of challenges that could benefit from the implementation of transport engineering technology. The range of challenges includes premature pathway termination due to secretion of intermediates, feedback inhibition due to inefficient export of final products, low yields in bioconversion processes due to inefficient import of precursors, and poor connectivity between subcellular compartments expressing different parts of complex biosynthetic pathways. We highlight the latest examples of transport engineering in microbial cell factories producing plant specialized metabolites, identify the current knowledge gap, and propose future research for advancing the field.

KW - Feedback inhibition

KW - Metabolic engineering

KW - Microbial cell factories

KW - Pathway engineering

KW - Plant specialized metabolites

KW - Transport engineering

U2 - 10.1016/j.cogsc.2021.100576

DO - 10.1016/j.cogsc.2021.100576

M3 - Review

AN - SCOPUS:85122105771

VL - 33

JO - Current Opinion in Green and Sustainable Chemistry

JF - Current Opinion in Green and Sustainable Chemistry

SN - 2452-2236

M1 - 100576

ER -

ID: 289158684