Non-coding Transcription

Contact research group leader

Sebastian Marquardt
Assistant Professor
M: sebastian.marquardt@plen.ku.dk
Ph: +45 35 33 13 05

Only a small proportion of DNA in higher organisms represents genes. Interestingly, most non-coding sequences are actively transcribed to yield long non-coding RNA (lncRNA). Gene promoters represent a conserved source of lncRNA through divergent non-coding transcription. However, the generated lncRNA molecules are not usually conserved, whereas genome-wide non-coding transcription is found in wide range of organisms.

Our lab is interested in the functional consequences of non-coding transcription independent of the lncRNA. We study how the mechanism of transcription of non-coding regions affects nearby gene expression through changes in chromatin packaging and modification. We are pursuing how this dynamic non-coding transcription may be part of plant environmental sensing mechanisms by studying transcription kinetics in environmental interactions.

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