Copper release from copper intrauterine devices removed after up to 8 years of use
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Copper release from copper intrauterine devices removed after up to 8 years of use. / Kjær, Andreas; Laursen, Kjeld; Thormann, Lene; Borggaard, Ole; Lebech, Paul Erik.
In: Contraception, Vol. 47, No. 4, 04.1993, p. 349-358.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Copper release from copper intrauterine devices removed after up to 8 years of use
AU - Kjær, Andreas
AU - Laursen, Kjeld
AU - Thormann, Lene
AU - Borggaard, Ole
AU - Lebech, Paul Erik
PY - 1993/4
Y1 - 1993/4
N2 - We studied the copper-releasing ability, weight and microscopic appearance of 2 copper-bearing intrauterine devices (IUDs), Copper-T Cu 200 (CuT) and Nova-T Cu 200 Ag (NovaT), after they had been in utero for up to 8 years. In addition, we studied whether IUDs removed from pregnant women showed different copper release. We found that IUD weight was a linear, negative function of duration of use, and that less than 20% of total copper would be released over a period of 8 years. The average copper-releasing ability was significantly higher for CuT than for NovaT (82.6 ± 6.4 vs. 42.7 ± 2.6 μg/day). The copper release was constant and thus unrelated to duration of use. Copper-releasing ability was similar in IUDs removed from pregnant and non-pregnant women. Fragmentation or minor defects only occurred in 3% of the IUDs and no correlation was found between deposits or corrosion and copper release rates. We conclude that CuT and NovaT both have constant copper release for at least 5-6 years and that the useful life-span probably can be prolonged to 6-8 years or more.
AB - We studied the copper-releasing ability, weight and microscopic appearance of 2 copper-bearing intrauterine devices (IUDs), Copper-T Cu 200 (CuT) and Nova-T Cu 200 Ag (NovaT), after they had been in utero for up to 8 years. In addition, we studied whether IUDs removed from pregnant women showed different copper release. We found that IUD weight was a linear, negative function of duration of use, and that less than 20% of total copper would be released over a period of 8 years. The average copper-releasing ability was significantly higher for CuT than for NovaT (82.6 ± 6.4 vs. 42.7 ± 2.6 μg/day). The copper release was constant and thus unrelated to duration of use. Copper-releasing ability was similar in IUDs removed from pregnant and non-pregnant women. Fragmentation or minor defects only occurred in 3% of the IUDs and no correlation was found between deposits or corrosion and copper release rates. We conclude that CuT and NovaT both have constant copper release for at least 5-6 years and that the useful life-span probably can be prolonged to 6-8 years or more.
UR - http://www.scopus.com/inward/record.url?scp=0027466743&partnerID=8YFLogxK
U2 - 10.1016/0010-7824(93)90032-3
DO - 10.1016/0010-7824(93)90032-3
M3 - Journal article
C2 - 8508664
AN - SCOPUS:0027466743
VL - 47
SP - 349
EP - 358
JO - Contraception
JF - Contraception
SN - 0010-7824
IS - 4
ER -
ID: 283516725