The plasma membrane H+-ATPase, a simple polypeptide with a long history
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The plasma membrane H+-ATPase of fungi and plants is a single polypeptide of fewer than 1,000 residues that extrudes protons from the cell against a large electric and concentration gradient. The minimalist structure of this nanomachine is in stark contrast to that of the large multi-subunit FOF1 ATPase of mitochondria, which is also a proton pump, but under physiological conditions runs in the reverse direction to act as an ATP synthase. The plasma membrane H+-ATPase is a P-type ATPase, defined by having an obligatory phosphorylated reaction cycle intermediate, like cation pumps of animal membranes, and thus, this pump has a completely different mechanism to that of FOF1 ATPases, which operates by rotary catalysis. The work that led to these insights in plasma membrane H+-ATPases of fungi and plants has a long history, which is briefly summarized in this review.
Original language | English |
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Journal | Yeast |
Volume | 36 |
Issue number | 4 |
Pages (from-to) | 201-210 |
ISSN | 0749-503X |
DOIs | |
Publication status | Published - Apr 2019 |
- Arabidopsis thaliana, F-type ATPase, Neurospora crassa, Nicotiana tabacum, P-type ATPase, proton pump, Saccharomyces cerevisiae, Schizosaccharomyces pombe
Research areas
Links
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590192/pdf/YEA-36-201.pdf
Final published version
ID: 213856468