P-type Pumps – University of Copenhagen

Contact research group leader

Michael Palmgren
Professor
M: palmgren@plen.ku.dk
Ph: +45 35 33 25 92

We study the structure, function and regulation of primary active transport across membranes. Our major focus is P-type ATPase pumps that form a large superfamily in all forms of life. P-type ATPases pump cations (like essential metals, calcium and protons) and phospholipids across membranes. Well-characterized members are essential for many basic functions in cells and we aim at assigning physiological function to other less characterized pumps. All members of this family form a phosphorylated reaction cycle intermediate, hence the name P-type, and their evolution raises unanswered questions that we try to answer. The pumping mechanism of these biological nanomachines and how pumping is regulated is also investigated.

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