Bacteria-triggered release of antimicrobial agents
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Bacteria-triggered release of antimicrobial agents. / Komnatnyy, Vitaly V; Chiang, Wen-Chi; Tolker-Nielsen, Tim; Givskov, Michael; Nielsen, Thomas E.
In: Angewandte Chemie (International ed. in English), Vol. 53, No. 2, 07.01.2014, p. 439-41.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bacteria-triggered release of antimicrobial agents
AU - Komnatnyy, Vitaly V
AU - Chiang, Wen-Chi
AU - Tolker-Nielsen, Tim
AU - Givskov, Michael
AU - Nielsen, Thomas E
N1 - Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2014/1/7
Y1 - 2014/1/7
N2 - Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.
AB - Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.
KW - Anhydrides
KW - Anti-Bacterial Agents
KW - Bacterial Adhesion
KW - Biofilms
KW - Lipase
KW - Molecular Structure
KW - Polymers
KW - Prostheses and Implants
KW - Prosthesis-Related Infections
KW - Pseudomonas aeruginosa
KW - Quorum Sensing
KW - Substrate Specificity
KW - Surface Properties
U2 - 10.1002/anie.201307975
DO - 10.1002/anie.201307975
M3 - Journal article
C2 - 24288347
VL - 53
SP - 439
EP - 441
JO - Angewandte Chemie International Edition
JF - Angewandte Chemie International Edition
SN - 1433-7851
IS - 2
ER -
ID: 129018745