High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus

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High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus. / Kyvsgaard, Julie Nyholm; Overgaard, Anne Julie; Thorsen, Steffen Ullitz; Hansen, Thomas Hesselhøj; Pipper, Christian Bressen; Mortensen, Henrik B.; Pociot, Flemming; Svensson, Jannet.

In: Nutrients, Vol. 9, No. 11, 1221, 2017.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Kyvsgaard, JN, Overgaard, AJ, Thorsen, SU, Hansen, TH, Pipper, CB, Mortensen, HB, Pociot, F & Svensson, J 2017, 'High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus', Nutrients, vol. 9, no. 11, 1221. https://doi.org/10.3390/nu9111221

APA

Kyvsgaard, J. N., Overgaard, A. J., Thorsen, S. U., Hansen, T. H., Pipper, C. B., Mortensen, H. B., ... Svensson, J. (2017). High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus. Nutrients, 9(11), [1221]. https://doi.org/10.3390/nu9111221

Vancouver

Kyvsgaard JN, Overgaard AJ, Thorsen SU, Hansen TH, Pipper CB, Mortensen HB et al. High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus. Nutrients. 2017;9(11). 1221. https://doi.org/10.3390/nu9111221

Author

Kyvsgaard, Julie Nyholm ; Overgaard, Anne Julie ; Thorsen, Steffen Ullitz ; Hansen, Thomas Hesselhøj ; Pipper, Christian Bressen ; Mortensen, Henrik B. ; Pociot, Flemming ; Svensson, Jannet. / High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus. In: Nutrients. 2017 ; Vol. 9, No. 11.

Bibtex

@article{2850f13916e945efb2bf6cebe9a4738c,
title = "High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus",
abstract = "(1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Information on confounders was available in 181 cases and 154 controls. Iron was measured on a neonatal single dried blood spot sample and was analyzed by laser ablation inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to evaluate if iron content in whole blood was associated with the risk of T1D; (3) Results: A doubling of iron content increased the odds of developing T1D more than two-fold (odds ratio (95{\%} CI), 2.55 (1.04; 6.24)). Iron content increased with maternal age (p = 0.04) and girls had higher content than boys (p = 0.01); (4) Conclusions: Higher neonatal iron content associates to an increased risk of developing T1D before the age of 16 years. Iron supplementation during early childhood needs further investigation, including the causes of high iron in neonates.",
keywords = "Journal Article",
author = "Kyvsgaard, {Julie Nyholm} and Overgaard, {Anne Julie} and Thorsen, {Steffen Ullitz} and Hansen, {Thomas Hesselh{\o}j} and Pipper, {Christian Bressen} and Mortensen, {Henrik B.} and Flemming Pociot and Jannet Svensson",
year = "2017",
doi = "10.3390/nu9111221",
language = "English",
volume = "9",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "11",

}

RIS

TY - JOUR

T1 - High neonatal blood iron content is associated with the risk of childhood type 1 diabetes mellitus

AU - Kyvsgaard, Julie Nyholm

AU - Overgaard, Anne Julie

AU - Thorsen, Steffen Ullitz

AU - Hansen, Thomas Hesselhøj

AU - Pipper, Christian Bressen

AU - Mortensen, Henrik B.

AU - Pociot, Flemming

AU - Svensson, Jannet

PY - 2017

Y1 - 2017

N2 - (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Information on confounders was available in 181 cases and 154 controls. Iron was measured on a neonatal single dried blood spot sample and was analyzed by laser ablation inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to evaluate if iron content in whole blood was associated with the risk of T1D; (3) Results: A doubling of iron content increased the odds of developing T1D more than two-fold (odds ratio (95% CI), 2.55 (1.04; 6.24)). Iron content increased with maternal age (p = 0.04) and girls had higher content than boys (p = 0.01); (4) Conclusions: Higher neonatal iron content associates to an increased risk of developing T1D before the age of 16 years. Iron supplementation during early childhood needs further investigation, including the causes of high iron in neonates.

AB - (1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth. Information on confounders was available in 181 cases and 154 controls. Iron was measured on a neonatal single dried blood spot sample and was analyzed by laser ablation inductively coupled plasma mass spectrometry. Multivariate logistic regression was used to evaluate if iron content in whole blood was associated with the risk of T1D; (3) Results: A doubling of iron content increased the odds of developing T1D more than two-fold (odds ratio (95% CI), 2.55 (1.04; 6.24)). Iron content increased with maternal age (p = 0.04) and girls had higher content than boys (p = 0.01); (4) Conclusions: Higher neonatal iron content associates to an increased risk of developing T1D before the age of 16 years. Iron supplementation during early childhood needs further investigation, including the causes of high iron in neonates.

KW - Journal Article

U2 - 10.3390/nu9111221

DO - 10.3390/nu9111221

M3 - Journal article

C2 - 29113123

VL - 9

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 11

M1 - 1221

ER -

ID: 185617106