Clinical translation of pluripotent stem cell-based therapies: successes and challenges
Research output: Contribution to journal › Journal article › Research › peer-review
The translational stem cell research field has progressed immensely in the past decade. Development and refinement of differentiation protocols now allows the generation of a range of cell types, such as pancreatic β-cells and dopaminergic neurons, from human pluripotent stem cells (hPSCs) in an efficient and good manufacturing practice-compliant fashion. This has led to the initiation of several clinical trials using hPSC-derived cells to replace lost or dysfunctional cells, demonstrating evidence of both safety and efficacy. Here, we highlight successes from some of the hPSC-based trials reporting early signs of efficacy and discuss common challenges in clinical translation of cell therapies.
Original language | English |
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Journal | Development (Cambridge, England) |
Volume | 151 |
Issue number | 7 |
ISSN | 0950-1991 |
DOIs | |
Publication status | Published - 1 Apr 2024 |
Bibliographical note
© 2024. Published by The Company of Biologists Ltd.
- Humans, Pluripotent Stem Cells, Cell Line, Cell Differentiation, Cell- and Tissue-Based Therapy, Stem Cell Research
Research areas
ID: 390195880