Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia? / Hegelund, Maria Hein; Ryrsø, Camilla Koch; Ritz, Christian; Dungu, Arnold Matovu; Sejdic, Adin; Jensen, Andreas V; Hansen, Nikita Misella; Mølgaard, Christian; Krogh-Madsen, Rikke; Lindegaard, Birgitte; Faurholt-Jepsen, Daniel.

In: Nutrients, Vol. 14, No. 22, 4906, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hegelund, MH, Ryrsø, CK, Ritz, C, Dungu, AM, Sejdic, A, Jensen, AV, Hansen, NM, Mølgaard, C, Krogh-Madsen, R, Lindegaard, B & Faurholt-Jepsen, D 2022, 'Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?', Nutrients, vol. 14, no. 22, 4906. https://doi.org/10.3390/nu14224906

APA

Hegelund, M. H., Ryrsø, C. K., Ritz, C., Dungu, A. M., Sejdic, A., Jensen, A. V., Hansen, N. M., Mølgaard, C., Krogh-Madsen, R., Lindegaard, B., & Faurholt-Jepsen, D. (2022). Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia? Nutrients, 14(22), [4906]. https://doi.org/10.3390/nu14224906

Vancouver

Hegelund MH, Ryrsø CK, Ritz C, Dungu AM, Sejdic A, Jensen AV et al. Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia? Nutrients. 2022;14(22). 4906. https://doi.org/10.3390/nu14224906

Author

Hegelund, Maria Hein ; Ryrsø, Camilla Koch ; Ritz, Christian ; Dungu, Arnold Matovu ; Sejdic, Adin ; Jensen, Andreas V ; Hansen, Nikita Misella ; Mølgaard, Christian ; Krogh-Madsen, Rikke ; Lindegaard, Birgitte ; Faurholt-Jepsen, Daniel. / Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?. In: Nutrients. 2022 ; Vol. 14, No. 22.

Bibtex

@article{810629067c6445fc98bb2fd7757af917,
title = "Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?",
abstract = "Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.",
keywords = "Faculty of Science, Community-acquired pneumonia, Undernutrition, Obesity, Re-hospitalization, Mortality",
author = "Hegelund, {Maria Hein} and Ryrs{\o}, {Camilla Koch} and Christian Ritz and Dungu, {Arnold Matovu} and Adin Sejdic and Jensen, {Andreas V} and Hansen, {Nikita Misella} and Christian M{\o}lgaard and Rikke Krogh-Madsen and Birgitte Lindegaard and Daniel Faurholt-Jepsen",
note = "CURIS 2022 NEXS 282",
year = "2022",
doi = "10.3390/nu14224906",
language = "English",
volume = "14",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "22",

}

RIS

TY - JOUR

T1 - Are undernutrition and obesity associated with post-discharge mortality and re-hospitalization after hospitalization with community-acquired pneumonia?

AU - Hegelund, Maria Hein

AU - Ryrsø, Camilla Koch

AU - Ritz, Christian

AU - Dungu, Arnold Matovu

AU - Sejdic, Adin

AU - Jensen, Andreas V

AU - Hansen, Nikita Misella

AU - Mølgaard, Christian

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Faurholt-Jepsen, Daniel

N1 - CURIS 2022 NEXS 282

PY - 2022

Y1 - 2022

N2 - Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.

AB - Undernutrition is associated with increased mortality after hospitalization with community-acquired pneumonia (CAP), whereas obesity is associated with decreased mortality in most studies. We aimed to determine whether undernutrition and obesity are associated with increased risk of re-hospitalization and post-discharge mortality after hospitalization. This study was nested within the Surviving Pneumonia cohort, which is a prospective cohort of adults hospitalized with CAP. Patients were categorized as undernourished, well-nourished, overweight, or obese. Undernutrition was based on diagnostic criteria by the European Society for Clinical Nutrition and Metabolism. Risk of mortality was investigated using multivariate logistic regression and re-hospitalization with competing risk Cox regression where death was the competing event. Compared to well-nourished patients, undernourished patients had a higher risk of 90-day (OR 3.0, 95% CI 1.0; 21.4) mortality, but a similar 30-day and 180-day mortality risk. Obese patients had a similar re-hospitalization and mortality risk as well-nourished patients. In conclusion, among patients with CAP, undernutrition was associated with increased risk of mortality. Undernourished patients are high-risk patients, and our results indicate that in-hospital screening of undernutrition should be implemented to identify patients at mortality risk. Studies are required to investigate whether nutritional therapy after hospitalization with CAP would improve survival.

KW - Faculty of Science

KW - Community-acquired pneumonia

KW - Undernutrition

KW - Obesity

KW - Re-hospitalization

KW - Mortality

U2 - 10.3390/nu14224906

DO - 10.3390/nu14224906

M3 - Journal article

C2 - 36432592

VL - 14

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 22

M1 - 4906

ER -

ID: 327124978