A higher healthy eating index is associated with decreased markers of inflammation and lower odds for being overweight/obese based on a case-control study
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A higher healthy eating index is associated with decreased markers of inflammation and lower odds for being overweight/obese based on a case-control study. / Vahid, Farhad; Jalili, Mahsa; Rahmani, Wena; Nasiri, Zahra; Bohn, Torsten.
In: Nutrients, Vol. 14, No. 23, 5127, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A higher healthy eating index is associated with decreased markers of inflammation and lower odds for being overweight/obese based on a case-control study
AU - Vahid, Farhad
AU - Jalili, Mahsa
AU - Rahmani, Wena
AU - Nasiri, Zahra
AU - Bohn, Torsten
N1 - CURIS 2022 NEXS 288
PY - 2022
Y1 - 2022
N2 - Obesity is a health risk characterized by chronic inflammation, and food choices are strongly associated with its etiology. Our objective was to investigate the association between dietary patterns and the healthy eating index (HEI) with the odds of overweight/obesity and related inflammatory markers. Within a population-based case-control study, we collected data and samples from 793 normal-weight and 812 overweight/obese Iranian people (based on either body mass index (BMI) or body surface area (BSA)). Dietary intake and HEI scores were obtained via a validated 124-item food frequency questionnaire. Anthropometric and socioeconomic parameters, as well as blood inflammatory markers, were measured. Participants with higher HEI scores had higher serum high-density lipoprotein-cholesterol (HDL-C) and significantly lower energy intake. Waterconsumption in the overweight/obese group was significantly lower than in the control group. In the final models using partial correlation and controlling for multiple confounders, there was a significant inverse correlation between HEI and interleukin-4 (IL-4, R = −0.063), IL-1β (R = −0.054), and high-sensitivity C-reactive protein (hs-CRP, R = −0.069). Based on multivariable logistic regression models adjusted for multiple confounders, there was a significant association between HEI as a continuous variable (OR = 0.993, 95% CI: 0.988–0.999) and categorical variable (OR = 0.801, 95% CI: 0.658–0.977)and odds of overweight/obesity across BMI groups. The dietary patterns in the case and control groups however were similar, and we failed to find a significant association between HEI and odds of overweight/obesity based on BSA. Adherence to healthy eating recommendations may be a prudent recommendation to prevent overweight/obesity and keeping inflammatory indicators low.
AB - Obesity is a health risk characterized by chronic inflammation, and food choices are strongly associated with its etiology. Our objective was to investigate the association between dietary patterns and the healthy eating index (HEI) with the odds of overweight/obesity and related inflammatory markers. Within a population-based case-control study, we collected data and samples from 793 normal-weight and 812 overweight/obese Iranian people (based on either body mass index (BMI) or body surface area (BSA)). Dietary intake and HEI scores were obtained via a validated 124-item food frequency questionnaire. Anthropometric and socioeconomic parameters, as well as blood inflammatory markers, were measured. Participants with higher HEI scores had higher serum high-density lipoprotein-cholesterol (HDL-C) and significantly lower energy intake. Waterconsumption in the overweight/obese group was significantly lower than in the control group. In the final models using partial correlation and controlling for multiple confounders, there was a significant inverse correlation between HEI and interleukin-4 (IL-4, R = −0.063), IL-1β (R = −0.054), and high-sensitivity C-reactive protein (hs-CRP, R = −0.069). Based on multivariable logistic regression models adjusted for multiple confounders, there was a significant association between HEI as a continuous variable (OR = 0.993, 95% CI: 0.988–0.999) and categorical variable (OR = 0.801, 95% CI: 0.658–0.977)and odds of overweight/obesity across BMI groups. The dietary patterns in the case and control groups however were similar, and we failed to find a significant association between HEI and odds of overweight/obesity based on BSA. Adherence to healthy eating recommendations may be a prudent recommendation to prevent overweight/obesity and keeping inflammatory indicators low.
KW - Faculty of Science
KW - Reactive oxygen species
KW - Immune system
KW - Antioxidants
KW - Cardiometabolic disease
KW - Cytokines
U2 - 10.3390/nu14235127
DO - 10.3390/nu14235127
M3 - Journal article
C2 - 36501156
VL - 14
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 23
M1 - 5127
ER -
ID: 327455297