Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. / Merelo, Paz; Ram, Hathi; Caggiano, Monica Pia; Ohno, Carolyn; Ott, Felix; Straub, Daniel; Graeff, Moritz; Cho, Seok Keun; Yang, Seong Wook; Wenkel, Stephan; Heisler, Marcus G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, No. 42, 2016, p. 11973-11978.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Merelo, P, Ram, H, Caggiano, MP, Ohno, C, Ott, F, Straub, D, Graeff, M, Cho, SK, Yang, SW, Wenkel, S & Heisler, MG 2016, 'Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity', Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 42, pp. 11973-11978. https://doi.org/10.1073/pnas.1516110113

APA

Merelo, P., Ram, H., Caggiano, M. P., Ohno, C., Ott, F., Straub, D., Graeff, M., Cho, S. K., Yang, S. W., Wenkel, S., & Heisler, M. G. (2016). Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. Proceedings of the National Academy of Sciences of the United States of America, 113(42), 11973-11978. https://doi.org/10.1073/pnas.1516110113

Vancouver

Merelo P, Ram H, Caggiano MP, Ohno C, Ott F, Straub D et al. Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(42):11973-11978. https://doi.org/10.1073/pnas.1516110113

Author

Merelo, Paz ; Ram, Hathi ; Caggiano, Monica Pia ; Ohno, Carolyn ; Ott, Felix ; Straub, Daniel ; Graeff, Moritz ; Cho, Seok Keun ; Yang, Seong Wook ; Wenkel, Stephan ; Heisler, Marcus G. / Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. In: Proceedings of the National Academy of Sciences of the United States of America. 2016 ; Vol. 113, No. 42. pp. 11973-11978.

Bibtex

@article{34328f2252144111866ef621803df692,
title = "Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity",
abstract = "A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.",
author = "Paz Merelo and Hathi Ram and Caggiano, {Monica Pia} and Carolyn Ohno and Felix Ott and Daniel Straub and Moritz Graeff and Cho, {Seok Keun} and Yang, {Seong Wook} and Stephan Wenkel and Heisler, {Marcus G.}",
year = "2016",
doi = "10.1073/pnas.1516110113",
language = "English",
volume = "113",
pages = "11973--11978",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "42",

}

RIS

TY - JOUR

T1 - Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

AU - Merelo, Paz

AU - Ram, Hathi

AU - Caggiano, Monica Pia

AU - Ohno, Carolyn

AU - Ott, Felix

AU - Straub, Daniel

AU - Graeff, Moritz

AU - Cho, Seok Keun

AU - Yang, Seong Wook

AU - Wenkel, Stephan

AU - Heisler, Marcus G.

PY - 2016

Y1 - 2016

N2 - A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.

AB - A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.

U2 - 10.1073/pnas.1516110113

DO - 10.1073/pnas.1516110113

M3 - Journal article

C2 - 27698117

VL - 113

SP - 11973

EP - 11978

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 42

ER -

ID: 167090059