We are working on the dynamic assembly of biosynthetic enzyme complexes, termed metabolons, for the production of phytochemicals. Plants produce an immense number of bioactive compounds with potential for applications as pharmaceuticals, colorants and flavors. Despite of the chemical diversity of phytochemicals, their biosynthesis involves a highly modular assembly of specific enzyme classes such as oxidoreductases, cytochromes P450 and transferases. Assembly of metabolons facilitates direct transfer of substrates and intermediates between sequential enzymes, which results in increased flux devoid of concomitant release of toxic or labile intermediates. We are interested in understanding how plants assemble metabolons on-demand in response to environmental challenges.

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