Plasticity of specialized metabolism as mediated by dynamic metabolons

Department of Plant and Environmental Sciences

Plasticity of specialized metabolism as mediated by dynamic metabolons

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasticity of specialized metabolism as mediated by dynamic metabolons. / Laursen, Tomas; Møller, Birger Lindberg; Bassard, Jean-Étienne André.

In: Trends in Plant Science, Vol. 20, No. 1, 2015, p. 20-32.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Laursen, T, Møller, BL & Bassard, J-ÉA 2015, 'Plasticity of specialized metabolism as mediated by dynamic metabolons', Trends in Plant Science, vol. 20, no. 1, pp. 20-32. https://doi.org/10.1016/j.tplants.2014.11.002

APA

Laursen, T., Møller, B. L., & Bassard, J-É. A. (2015). Plasticity of specialized metabolism as mediated by dynamic metabolons. Trends in Plant Science, 20(1), 20-32. https://doi.org/10.1016/j.tplants.2014.11.002

Vancouver

Laursen T, Møller BL, Bassard J-ÉA. Plasticity of specialized metabolism as mediated by dynamic metabolons. Trends in Plant Science. 2015;20(1):20-32. https://doi.org/10.1016/j.tplants.2014.11.002

Author

Laursen, Tomas ; Møller, Birger Lindberg ; Bassard, Jean-Étienne André. / Plasticity of specialized metabolism as mediated by dynamic metabolons. In: Trends in Plant Science. 2015 ; Vol. 20, No. 1. pp. 20-32.

Bibtex

@article{8ececea7bf0d49bbaf80488e3868b583,

title = "Plasticity of specialized metabolism as mediated by dynamic metabolons",

abstract = "The formation of specialized metabolites enables plants to respond to biotic and abiotic stresses, but requires the sequential action of multiple enzymes. To facilitate swift production and to avoid leakage of potentially toxic and labile intermediates, many of the biosynthetic pathways are thought to organize in multienzyme clusters termed metabolons. Dynamic assembly and disassembly enable the plant to rapidly switch the product profile and thereby prioritize its resources. The lifetime of metabolons is largely unknown mainly due to technological limitations. This review focuses on the factors that facilitate and stimulate the dynamic assembly of metabolons, including microenvironments, noncatalytic proteins, and allosteric regulation. Understanding how plants organize carbon fluxes within their metabolic grids would enable targeted bioengineering of high-value specialized metabolites.",

author = "Tomas Laursen and M{\o}ller, {Birger Lindberg} and Bassard, {Jean-{\'E}tienne Andr{\'e}}",

year = "2015",

doi = "10.1016/j.tplants.2014.11.002",

language = "English",

volume = "20",

pages = "20--32",

journal = "Trends in Plant Science",

issn = "1360-1385",

publisher = "Elsevier Ltd. * Trends Journals",

number = "1",

}

RIS

TY - JOUR

T1 - Plasticity of specialized metabolism as mediated by dynamic metabolons

AU - Laursen, Tomas

AU - Møller, Birger Lindberg

AU - Bassard, Jean-Étienne André

PY - 2015

Y1 - 2015

N2 - The formation of specialized metabolites enables plants to respond to biotic and abiotic stresses, but requires the sequential action of multiple enzymes. To facilitate swift production and to avoid leakage of potentially toxic and labile intermediates, many of the biosynthetic pathways are thought to organize in multienzyme clusters termed metabolons. Dynamic assembly and disassembly enable the plant to rapidly switch the product profile and thereby prioritize its resources. The lifetime of metabolons is largely unknown mainly due to technological limitations. This review focuses on the factors that facilitate and stimulate the dynamic assembly of metabolons, including microenvironments, noncatalytic proteins, and allosteric regulation. Understanding how plants organize carbon fluxes within their metabolic grids would enable targeted bioengineering of high-value specialized metabolites.

AB - The formation of specialized metabolites enables plants to respond to biotic and abiotic stresses, but requires the sequential action of multiple enzymes. To facilitate swift production and to avoid leakage of potentially toxic and labile intermediates, many of the biosynthetic pathways are thought to organize in multienzyme clusters termed metabolons. Dynamic assembly and disassembly enable the plant to rapidly switch the product profile and thereby prioritize its resources. The lifetime of metabolons is largely unknown mainly due to technological limitations. This review focuses on the factors that facilitate and stimulate the dynamic assembly of metabolons, including microenvironments, noncatalytic proteins, and allosteric regulation. Understanding how plants organize carbon fluxes within their metabolic grids would enable targeted bioengineering of high-value specialized metabolites.

U2 - 10.1016/j.tplants.2014.11.002

DO - 10.1016/j.tplants.2014.11.002

M3 - Journal article

C2 - 25435320

VL - 20

SP - 20

EP - 32

JO - Trends in Plant Science

JF - Trends in Plant Science

SN - 1360-1385

IS - 1

ER -

ID: 131443836