Biophysical study of resin acid effects on phospholipid membrane structure and properties

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Biophysical study of resin acid effects on phospholipid membrane structure and properties. / Jagalski, Vivien; Barker, Robert; Topgaard, Daniel; Günther-Pomorski, Thomas; Hamberger, Björn Robert; Cardenas Gomez, Marite.

In: BBA Biomembranes, Vol. 1858, No. 11, 2016, p. 2827-2838.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jagalski, V, Barker, R, Topgaard, D, Günther-Pomorski, T, Hamberger, BR & Cardenas Gomez, M 2016, 'Biophysical study of resin acid effects on phospholipid membrane structure and properties', BBA Biomembranes, vol. 1858, no. 11, pp. 2827-2838. https://doi.org/10.1016/j.bbamem.2016.08.008

APA

Jagalski, V., Barker, R., Topgaard, D., Günther-Pomorski, T., Hamberger, B. R., & Cardenas Gomez, M. (2016). Biophysical study of resin acid effects on phospholipid membrane structure and properties. BBA Biomembranes, 1858(11), 2827-2838. https://doi.org/10.1016/j.bbamem.2016.08.008

Vancouver

Jagalski V, Barker R, Topgaard D, Günther-Pomorski T, Hamberger BR, Cardenas Gomez M. Biophysical study of resin acid effects on phospholipid membrane structure and properties. BBA Biomembranes. 2016;1858(11):2827-2838. https://doi.org/10.1016/j.bbamem.2016.08.008

Author

Jagalski, Vivien ; Barker, Robert ; Topgaard, Daniel ; Günther-Pomorski, Thomas ; Hamberger, Björn Robert ; Cardenas Gomez, Marite. / Biophysical study of resin acid effects on phospholipid membrane structure and properties. In: BBA Biomembranes. 2016 ; Vol. 1858, No. 11. pp. 2827-2838.

Bibtex

@article{7ac1c548ed0f44d78480fd6f5243c9d8,
title = "Biophysical study of resin acid effects on phospholipid membrane structure and properties",
abstract = "Hydrophobic resin acids (RAs) are synthesized by conifer trees as part of their defense mechanisms. One of the functions of RAs in plant defense is suggested to be the perturbation of the cellular membrane. However, there is a vast diversity of chemical structures within this class of molecules, and there are no clear correlations to the molecular mechanisms behind the RA's toxicity. In this study we unravel the molecular interactions of the three closely related RAs dehydroabietic acid, neoabietic acid, and the synthetic analogue dichlorodehydroabietic acid with dipalmitoylphosphatidylcholine (DPPC) model membranes and the polar lipid extract of soybeans. The complementarity of the biophysical techniques used (NMR, DLS, NR, DSC, Cryo-TEM) allowed correlating changes at the vesicle level with changes at the molecular level and the co-localization of RAs within DPPC monolayer. Effects on DPPC membranes are correlated with the physical chemical properties of the RA and their toxicity.",
author = "Vivien Jagalski and Robert Barker and Daniel Topgaard and Thomas G{\"u}nther-Pomorski and Hamberger, {Bj{\"o}rn Robert} and {Cardenas Gomez}, Marite",
note = "Copyright {\textcopyright} 2016 Elsevier B.V. All rights reserved.",
year = "2016",
doi = "10.1016/j.bbamem.2016.08.008",
language = "English",
volume = "1858",
pages = "2827--2838",
journal = "B B A - Biomembranes",
issn = "0005-2736",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Biophysical study of resin acid effects on phospholipid membrane structure and properties

AU - Jagalski, Vivien

AU - Barker, Robert

AU - Topgaard, Daniel

AU - Günther-Pomorski, Thomas

AU - Hamberger, Björn Robert

AU - Cardenas Gomez, Marite

N1 - Copyright © 2016 Elsevier B.V. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Hydrophobic resin acids (RAs) are synthesized by conifer trees as part of their defense mechanisms. One of the functions of RAs in plant defense is suggested to be the perturbation of the cellular membrane. However, there is a vast diversity of chemical structures within this class of molecules, and there are no clear correlations to the molecular mechanisms behind the RA's toxicity. In this study we unravel the molecular interactions of the three closely related RAs dehydroabietic acid, neoabietic acid, and the synthetic analogue dichlorodehydroabietic acid with dipalmitoylphosphatidylcholine (DPPC) model membranes and the polar lipid extract of soybeans. The complementarity of the biophysical techniques used (NMR, DLS, NR, DSC, Cryo-TEM) allowed correlating changes at the vesicle level with changes at the molecular level and the co-localization of RAs within DPPC monolayer. Effects on DPPC membranes are correlated with the physical chemical properties of the RA and their toxicity.

AB - Hydrophobic resin acids (RAs) are synthesized by conifer trees as part of their defense mechanisms. One of the functions of RAs in plant defense is suggested to be the perturbation of the cellular membrane. However, there is a vast diversity of chemical structures within this class of molecules, and there are no clear correlations to the molecular mechanisms behind the RA's toxicity. In this study we unravel the molecular interactions of the three closely related RAs dehydroabietic acid, neoabietic acid, and the synthetic analogue dichlorodehydroabietic acid with dipalmitoylphosphatidylcholine (DPPC) model membranes and the polar lipid extract of soybeans. The complementarity of the biophysical techniques used (NMR, DLS, NR, DSC, Cryo-TEM) allowed correlating changes at the vesicle level with changes at the molecular level and the co-localization of RAs within DPPC monolayer. Effects on DPPC membranes are correlated with the physical chemical properties of the RA and their toxicity.

U2 - 10.1016/j.bbamem.2016.08.008

DO - 10.1016/j.bbamem.2016.08.008

M3 - Journal article

C2 - 27544924

VL - 1858

SP - 2827

EP - 2838

JO - B B A - Biomembranes

JF - B B A - Biomembranes

SN - 0005-2736

IS - 11

ER -

ID: 169106640