Antifungal constituents of Melicope borbonica
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Antifungal constituents of Melicope borbonica. / Simonsen, Henrik Toft; Adsersen, Anne; Bremner, Paul; Heinrich, Michael; Wagner Smitt, Ulla; Jaroszewski, Jerzy W.
In: Phytotherapy Research, Vol. 18, No. 7, 07.2004, p. 542-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Antifungal constituents of Melicope borbonica
AU - Simonsen, Henrik Toft
AU - Adsersen, Anne
AU - Bremner, Paul
AU - Heinrich, Michael
AU - Wagner Smitt, Ulla
AU - Jaroszewski, Jerzy W
PY - 2004/7
Y1 - 2004/7
N2 - Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.
AB - Fractionation of extracts of the leaves of Melicope borbonica (syn. Euodia borbonica var. borbonica), a medicinal plant from the Réunion Island that is traditionally used for wound healing and other ailments, afforded an acetophenone (xanthoxylin) and two coumarins, scoparone and limettin, as the major constituents. All three compounds exhibited moderate antifungal activity against Candida albicans and Penicillium expansum, in accordance with the traditional use of the plant. Moreover, 2,4,6-trimethoxyacetophenone (methylxanthoxylin), three other coumarins [7-(3-methyl-2-butenyloxy)-6-methoxycoumarin, cedrelopsin and psoralen], two sesquiterpenes (alpha-curcumene and 3,6-epidioxy-1,10-bisaboladiene), eugenol, methyleugenol and a lignan (sesamin) were isolated. None of the isolated constituents exhibited antiin fl ammatory activity in vitro. No alkaloids were detected.
KW - Antifungal Agents
KW - Candida albicans
KW - Humans
KW - Microbial Sensitivity Tests
KW - Penicillium
KW - Phytotherapy
KW - Plant Extracts
KW - Plant Leaves
KW - Rutaceae
KW - Wound Healing
U2 - 10.1002/ptr.1482
DO - 10.1002/ptr.1482
M3 - Journal article
C2 - 15305313
VL - 18
SP - 542
EP - 545
JO - Phytotherapy Research
JF - Phytotherapy Research
SN - 0951-418X
IS - 7
ER -
ID: 128570986