Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

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Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. / Daskalaki, Maria G; Tsatsanis, Christos; Kampranis, Sotirios C.

In: Journal of Cellular Physiology, Vol. 233, No. 9, 2018, p. 6495-6507.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Daskalaki, MG, Tsatsanis, C & Kampranis, SC 2018, 'Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses', Journal of Cellular Physiology, vol. 233, no. 9, pp. 6495-6507. https://doi.org/10.1002/jcp.26497

APA

Daskalaki, M. G., Tsatsanis, C., & Kampranis, S. C. (2018). Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. Journal of Cellular Physiology, 233(9), 6495-6507. https://doi.org/10.1002/jcp.26497

Vancouver

Daskalaki MG, Tsatsanis C, Kampranis SC. Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. Journal of Cellular Physiology. 2018;233(9):6495-6507. https://doi.org/10.1002/jcp.26497

Author

Daskalaki, Maria G ; Tsatsanis, Christos ; Kampranis, Sotirios C. / Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses. In: Journal of Cellular Physiology. 2018 ; Vol. 233, No. 9. pp. 6495-6507.

Bibtex

@article{d892e6a193a2493688b35c11fe67a5b2,
title = "Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses",
abstract = "Macrophages respond to noxious stimuli and contribute to inflammatory responses by eliminating pathogens or damaged tissue and maintaining homeostasis. Response to activation signals and maintenance of homeostasis require tight regulation of genes involved in macrophage activation and inactivation processes, as well as genes involved in determining their polarization state. Recent evidence has revealed that such regulation occurs through histone modifications that render inflammatory or polarizing gene promoters accessible to transcriptional complexes. Thus, inflammatory and anti-inflammatory genes are regulated by histone acetylation and methylation, determining their activation state. Herein, we review the current knowledge on the role of histone modifying enzymes (acetyltransferases, deacetylases, methyltransferases, and demethylases) in determining the responsiveness and M1 or M2 polarization of macrophages. The contribution of these enzymes in the development of inflammatory diseases is also presented.",
author = "Daskalaki, {Maria G} and Christos Tsatsanis and Kampranis, {Sotirios C.}",
year = "2018",
doi = "10.1002/jcp.26497",
language = "English",
volume = "233",
pages = "6495--6507",
journal = "Journal of Cellular Physiology",
issn = "0021-9541",
publisher = "JohnWiley & Sons, Inc.",
number = "9",

}

RIS

TY - JOUR

T1 - Histone methylation and acetylation in macrophages as a mechanism for regulation of inflammatory responses

AU - Daskalaki, Maria G

AU - Tsatsanis, Christos

AU - Kampranis, Sotirios C.

PY - 2018

Y1 - 2018

N2 - Macrophages respond to noxious stimuli and contribute to inflammatory responses by eliminating pathogens or damaged tissue and maintaining homeostasis. Response to activation signals and maintenance of homeostasis require tight regulation of genes involved in macrophage activation and inactivation processes, as well as genes involved in determining their polarization state. Recent evidence has revealed that such regulation occurs through histone modifications that render inflammatory or polarizing gene promoters accessible to transcriptional complexes. Thus, inflammatory and anti-inflammatory genes are regulated by histone acetylation and methylation, determining their activation state. Herein, we review the current knowledge on the role of histone modifying enzymes (acetyltransferases, deacetylases, methyltransferases, and demethylases) in determining the responsiveness and M1 or M2 polarization of macrophages. The contribution of these enzymes in the development of inflammatory diseases is also presented.

AB - Macrophages respond to noxious stimuli and contribute to inflammatory responses by eliminating pathogens or damaged tissue and maintaining homeostasis. Response to activation signals and maintenance of homeostasis require tight regulation of genes involved in macrophage activation and inactivation processes, as well as genes involved in determining their polarization state. Recent evidence has revealed that such regulation occurs through histone modifications that render inflammatory or polarizing gene promoters accessible to transcriptional complexes. Thus, inflammatory and anti-inflammatory genes are regulated by histone acetylation and methylation, determining their activation state. Herein, we review the current knowledge on the role of histone modifying enzymes (acetyltransferases, deacetylases, methyltransferases, and demethylases) in determining the responsiveness and M1 or M2 polarization of macrophages. The contribution of these enzymes in the development of inflammatory diseases is also presented.

U2 - 10.1002/jcp.26497

DO - 10.1002/jcp.26497

M3 - Review

C2 - 29574768

VL - 233

SP - 6495

EP - 6507

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

SN - 0021-9541

IS - 9

ER -

ID: 209366794