FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. / Kottakis, Filippos; Polytarchou, Christos; Foltopoulou, Parthena; Sanidas, Ioannis; Kampranis, Sotirios; Tsichlis, Philip N.

In: Molecular Cell, Vol. 43, No. 2, 22.07.2011, p. 285-98.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kottakis, F, Polytarchou, C, Foltopoulou, P, Sanidas, I, Kampranis, S & Tsichlis, PN 2011, 'FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway', Molecular Cell, vol. 43, no. 2, pp. 285-98. https://doi.org/10.1016/j.molcel.2011.06.020

APA

Kottakis, F., Polytarchou, C., Foltopoulou, P., Sanidas, I., Kampranis, S., & Tsichlis, P. N. (2011). FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Molecular Cell, 43(2), 285-98. https://doi.org/10.1016/j.molcel.2011.06.020

Vancouver

Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis S, Tsichlis PN. FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. Molecular Cell. 2011 Jul 22;43(2):285-98. https://doi.org/10.1016/j.molcel.2011.06.020

Author

Kottakis, Filippos ; Polytarchou, Christos ; Foltopoulou, Parthena ; Sanidas, Ioannis ; Kampranis, Sotirios ; Tsichlis, Philip N. / FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway. In: Molecular Cell. 2011 ; Vol. 43, No. 2. pp. 285-98.

Bibtex

@article{342b4c08c0374be69dfeb1fec26e90ca,
title = "FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway",
abstract = "The histone H3K27 methyltransferase EZH2 plays an important role in oncogenesis, by mechanisms that are incompletely understood. Here, we show that the JmjC domain histone H3 demethylase NDY1 synergizes with EZH2 to silence the EZH2 inhibitor miR-101. NDY1 and EZH2 repress miR-101 by binding its promoter in concert, via a process triggered by upregulation of NDY1. Whereas EZH2 binding depends on NDY1, the latter binds independently of EZH2. However, both are required to repress transcription. NDY1 and EZH2 acting in concert upregulate EZH2 and stabilize the repression of miR-101 and its outcome. NDY1 is induced by FGF-2 via CREB phosphorylation and activation, downstream of DYRK1A, and mediates the FGF-2 and EZH2 effects on cell proliferation, migration, and angiogenesis. The FGF-2-NDY1/EZH2-miR-101-EZH2 axis described here was found to be active in bladder cancer. These data delineate an oncogenic pathway that functionally links FGF-2 with EZH2 via NDY1 and miR-101.",
keywords = "Animals, Cell Line, Tumor, Cell Movement, Cell Proliferation, DNA-Binding Proteins, F-Box Proteins, Fibroblast Growth Factor 2, Histone Demethylases, Histone-Lysine N-Methyltransferase, Humans, Jumonji Domain-Containing Histone Demethylases, Mice, MicroRNAs, Neovascularization, Physiologic, Oxidoreductases, N-Demethylating, Polycomb Repressive Complex 2, Transcription Factors",
author = "Filippos Kottakis and Christos Polytarchou and Parthena Foltopoulou and Ioannis Sanidas and Sotirios Kampranis and Tsichlis, {Philip N}",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = jul,
day = "22",
doi = "10.1016/j.molcel.2011.06.020",
language = "English",
volume = "43",
pages = "285--98",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway

AU - Kottakis, Filippos

AU - Polytarchou, Christos

AU - Foltopoulou, Parthena

AU - Sanidas, Ioannis

AU - Kampranis, Sotirios

AU - Tsichlis, Philip N

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/7/22

Y1 - 2011/7/22

N2 - The histone H3K27 methyltransferase EZH2 plays an important role in oncogenesis, by mechanisms that are incompletely understood. Here, we show that the JmjC domain histone H3 demethylase NDY1 synergizes with EZH2 to silence the EZH2 inhibitor miR-101. NDY1 and EZH2 repress miR-101 by binding its promoter in concert, via a process triggered by upregulation of NDY1. Whereas EZH2 binding depends on NDY1, the latter binds independently of EZH2. However, both are required to repress transcription. NDY1 and EZH2 acting in concert upregulate EZH2 and stabilize the repression of miR-101 and its outcome. NDY1 is induced by FGF-2 via CREB phosphorylation and activation, downstream of DYRK1A, and mediates the FGF-2 and EZH2 effects on cell proliferation, migration, and angiogenesis. The FGF-2-NDY1/EZH2-miR-101-EZH2 axis described here was found to be active in bladder cancer. These data delineate an oncogenic pathway that functionally links FGF-2 with EZH2 via NDY1 and miR-101.

AB - The histone H3K27 methyltransferase EZH2 plays an important role in oncogenesis, by mechanisms that are incompletely understood. Here, we show that the JmjC domain histone H3 demethylase NDY1 synergizes with EZH2 to silence the EZH2 inhibitor miR-101. NDY1 and EZH2 repress miR-101 by binding its promoter in concert, via a process triggered by upregulation of NDY1. Whereas EZH2 binding depends on NDY1, the latter binds independently of EZH2. However, both are required to repress transcription. NDY1 and EZH2 acting in concert upregulate EZH2 and stabilize the repression of miR-101 and its outcome. NDY1 is induced by FGF-2 via CREB phosphorylation and activation, downstream of DYRK1A, and mediates the FGF-2 and EZH2 effects on cell proliferation, migration, and angiogenesis. The FGF-2-NDY1/EZH2-miR-101-EZH2 axis described here was found to be active in bladder cancer. These data delineate an oncogenic pathway that functionally links FGF-2 with EZH2 via NDY1 and miR-101.

KW - Animals

KW - Cell Line, Tumor

KW - Cell Movement

KW - Cell Proliferation

KW - DNA-Binding Proteins

KW - F-Box Proteins

KW - Fibroblast Growth Factor 2

KW - Histone Demethylases

KW - Histone-Lysine N-Methyltransferase

KW - Humans

KW - Jumonji Domain-Containing Histone Demethylases

KW - Mice

KW - MicroRNAs

KW - Neovascularization, Physiologic

KW - Oxidoreductases, N-Demethylating

KW - Polycomb Repressive Complex 2

KW - Transcription Factors

U2 - 10.1016/j.molcel.2011.06.020

DO - 10.1016/j.molcel.2011.06.020

M3 - Journal article

C2 - 21777817

VL - 43

SP - 285

EP - 298

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 2

ER -

ID: 159084888