Developing a yeast cell factory for the production of terpenoids
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Developing a yeast cell factory for the production of terpenoids. / Kampranis, Sotirios; Makris, Antonios M.
In: Computational and Structural Biotechnology Journal, Vol. 3, 2012, p. e201210006.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Developing a yeast cell factory for the production of terpenoids
AU - Kampranis, Sotirios
AU - Makris, Antonios M
PY - 2012
Y1 - 2012
N2 - Technological developments over the past century have made microbes the work-horses of large scale industrial production processes. Current efforts focus on the metabolic engineering of microbial strains to produce high levels of desirable end-products. The arsenal of the contemporary metabolic engineer contains tools that allow either targeted rational interventions or global screens that combine classical approaches with -omics technologies. Production of terpenoids in S. cerevisiae presents a characteristic example of contemporary biotechnology that integrates all the variety of novel approaches used in metabolic engineering. Terpenoids have attracted significant interest as pharmaceuticals, flavour and fragrance additives, and, more recently, biofuels. The ongoing metabolic engineering efforts, combined with the continuously increasing number of terpene biosynthetic enzymes discovered will enable the economical and environmentally friendly production of a wide range of compounds.
AB - Technological developments over the past century have made microbes the work-horses of large scale industrial production processes. Current efforts focus on the metabolic engineering of microbial strains to produce high levels of desirable end-products. The arsenal of the contemporary metabolic engineer contains tools that allow either targeted rational interventions or global screens that combine classical approaches with -omics technologies. Production of terpenoids in S. cerevisiae presents a characteristic example of contemporary biotechnology that integrates all the variety of novel approaches used in metabolic engineering. Terpenoids have attracted significant interest as pharmaceuticals, flavour and fragrance additives, and, more recently, biofuels. The ongoing metabolic engineering efforts, combined with the continuously increasing number of terpene biosynthetic enzymes discovered will enable the economical and environmentally friendly production of a wide range of compounds.
U2 - 10.5936/csbj.201210006
DO - 10.5936/csbj.201210006
M3 - Journal article
C2 - 24688666
VL - 3
SP - e201210006
JO - Computational and Structural Biotechnology Journal
JF - Computational and Structural Biotechnology Journal
SN - 2001-0370
ER -
ID: 159084859