Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae)

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Standard

Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae). / Knudsen, Diana Jæger; Simpson, Bradley S.; Ndi, Chi P.; Jäger, Anna; Crocoll, Christoph; Møller, Birger Lindberg; Weinstein, Philip; Semple, Susan J.

In: Natural Product Research, Vol. 32, No. 5, 2018, p. 576-581.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Knudsen, DJ, Simpson, BS, Ndi, CP, Jäger, A, Crocoll, C, Møller, BL, Weinstein, P & Semple, SJ 2018, 'Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae)', Natural Product Research, vol. 32, no. 5, pp. 576-581. https://doi.org/10.1080/14786419.2017.1318383

APA

Knudsen, D. J., Simpson, B. S., Ndi, C. P., Jäger, A., Crocoll, C., Møller, B. L., Weinstein, P., & Semple, S. J. (2018). Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae). Natural Product Research, 32(5), 576-581. https://doi.org/10.1080/14786419.2017.1318383

Vancouver

Knudsen DJ, Simpson BS, Ndi CP, Jäger A, Crocoll C, Møller BL et al. Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae). Natural Product Research. 2018;32(5):576-581. https://doi.org/10.1080/14786419.2017.1318383

Author

Knudsen, Diana Jæger ; Simpson, Bradley S. ; Ndi, Chi P. ; Jäger, Anna ; Crocoll, Christoph ; Møller, Birger Lindberg ; Weinstein, Philip ; Semple, Susan J. / Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae). In: Natural Product Research. 2018 ; Vol. 32, No. 5. pp. 576-581.

Bibtex

@article{9b7eeb9d48194085b34169de1181cd83,
title = "Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae)",
abstract = "Acacia ligulata A.Cunn. ex Benth. (Fabaceae: Mimosoideae) is a native Australian plant used traditionally by Australian Aboriginal groups. This study was undertaken to investigate the bioactivity of A. ligulata extracts and to evaluate their chemical composition. Potential antibacterial, cytotoxic and enzyme inhibitory effects relevant to traditional medicinal and food uses of the species were examined and LC-MS/MS was performed to investigate the chemical composition. Antibacterial activity was observed for bark and leaf extracts with an MIC for the bark extract of 62.5 μg/mL against Streptococcus pyogenes. Pod extracts showed cytotoxic effects against cancer cells, with the highest activity against melanoma SK-MEL28 cells with IC50 values between 40.8 and 80.6 μg/mL. Further, the leaf and pod extracts also inhibited α-amylase EC-3.2.1.1 and α-glucosidase EC-3.2.1.20 with IC50 values between 9.7-34.8 and 12.6-64.3 μg/mL, respectively. The LC-MS/MS profiling indicated that several different saponins were present in the active extracts.",
keywords = "Journal Article",
author = "Knudsen, {Diana J{\ae}ger} and Simpson, {Bradley S.} and Ndi, {Chi P.} and Anna J{\"a}ger and Christoph Crocoll and M{\o}ller, {Birger Lindberg} and Philip Weinstein and Semple, {Susan J.}",
year = "2018",
doi = "10.1080/14786419.2017.1318383",
language = "English",
volume = "32",
pages = "576--581",
journal = "Natural Product Research",
issn = "1478-6419",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae)

AU - Knudsen, Diana Jæger

AU - Simpson, Bradley S.

AU - Ndi, Chi P.

AU - Jäger, Anna

AU - Crocoll, Christoph

AU - Møller, Birger Lindberg

AU - Weinstein, Philip

AU - Semple, Susan J.

PY - 2018

Y1 - 2018

N2 - Acacia ligulata A.Cunn. ex Benth. (Fabaceae: Mimosoideae) is a native Australian plant used traditionally by Australian Aboriginal groups. This study was undertaken to investigate the bioactivity of A. ligulata extracts and to evaluate their chemical composition. Potential antibacterial, cytotoxic and enzyme inhibitory effects relevant to traditional medicinal and food uses of the species were examined and LC-MS/MS was performed to investigate the chemical composition. Antibacterial activity was observed for bark and leaf extracts with an MIC for the bark extract of 62.5 μg/mL against Streptococcus pyogenes. Pod extracts showed cytotoxic effects against cancer cells, with the highest activity against melanoma SK-MEL28 cells with IC50 values between 40.8 and 80.6 μg/mL. Further, the leaf and pod extracts also inhibited α-amylase EC-3.2.1.1 and α-glucosidase EC-3.2.1.20 with IC50 values between 9.7-34.8 and 12.6-64.3 μg/mL, respectively. The LC-MS/MS profiling indicated that several different saponins were present in the active extracts.

AB - Acacia ligulata A.Cunn. ex Benth. (Fabaceae: Mimosoideae) is a native Australian plant used traditionally by Australian Aboriginal groups. This study was undertaken to investigate the bioactivity of A. ligulata extracts and to evaluate their chemical composition. Potential antibacterial, cytotoxic and enzyme inhibitory effects relevant to traditional medicinal and food uses of the species were examined and LC-MS/MS was performed to investigate the chemical composition. Antibacterial activity was observed for bark and leaf extracts with an MIC for the bark extract of 62.5 μg/mL against Streptococcus pyogenes. Pod extracts showed cytotoxic effects against cancer cells, with the highest activity against melanoma SK-MEL28 cells with IC50 values between 40.8 and 80.6 μg/mL. Further, the leaf and pod extracts also inhibited α-amylase EC-3.2.1.1 and α-glucosidase EC-3.2.1.20 with IC50 values between 9.7-34.8 and 12.6-64.3 μg/mL, respectively. The LC-MS/MS profiling indicated that several different saponins were present in the active extracts.

KW - Journal Article

U2 - 10.1080/14786419.2017.1318383

DO - 10.1080/14786419.2017.1318383

M3 - Journal article

C2 - 28427277

VL - 32

SP - 576

EP - 581

JO - Natural Product Research

JF - Natural Product Research

SN - 1478-6419

IS - 5

ER -

ID: 177067750