2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora : High-resolution inhibition profiling and PTP1B inhibitory activity. / Zhao, Yong; Kjaerulff, Louise; Kongstad, Kenneth Thermann; Heskes, Allison Maree; Møller, Birger Lindberg; Stærk, Dan.

In: Phytochemistry, Vol. 166, 112054, 2019, p. 1-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhao, Y, Kjaerulff, L, Kongstad, KT, Heskes, AM, Møller, BL & Stærk, D 2019, '2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity', Phytochemistry, vol. 166, 112054, pp. 1-8. https://doi.org/10.1016/j.phytochem.2019.112054

APA

Zhao, Y., Kjaerulff, L., Kongstad, K. T., Heskes, A. M., Møller, B. L., & Stærk, D. (2019). 2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity. Phytochemistry, 166, 1-8. [112054]. https://doi.org/10.1016/j.phytochem.2019.112054

Vancouver

Zhao Y, Kjaerulff L, Kongstad KT, Heskes AM, Møller BL, Stærk D. 2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity. Phytochemistry. 2019;166:1-8. 112054. https://doi.org/10.1016/j.phytochem.2019.112054

Author

Zhao, Yong ; Kjaerulff, Louise ; Kongstad, Kenneth Thermann ; Heskes, Allison Maree ; Møller, Birger Lindberg ; Stærk, Dan. / 2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora : High-resolution inhibition profiling and PTP1B inhibitory activity. In: Phytochemistry. 2019 ; Vol. 166. pp. 1-8.

Bibtex

@article{4da04b305a4b435abeec80787f27d92b,
title = "2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity",
abstract = "Eremophila bignoniiflora is a shrub distributed throughout inland northern and eastern Australia, and it has been used in several medicinal applications by some Australian Aboriginal people. In our continued search for anti-diabetic constituents from natural resources, the crude ethyl acetate extract of E. bignoniiflora was found to have protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 23.9 ± 1.9 μg/mL. High-resolution PTP1B inhibition profiling combined with HRMS and NMR were subsequently used to investigate the individual compounds responsible for the observed bioactivity of the crude extract. This led to identification of five undescribed 2(5H)-furanone sesquiterpenes, together with 13 flavonoids and phenolic compounds. Dose-response curves of the isolated compounds revealed that two 2(5H)-furanone sesquiterpene cinnamates and three flavonoids exhibited moderate PTP1B inhibitory activity with IC50 values from 41.4 ± 1.4 to 154.5 ± 8.9 μM.",
author = "Yong Zhao and Louise Kjaerulff and Kongstad, {Kenneth Thermann} and Heskes, {Allison Maree} and M{\o}ller, {Birger Lindberg} and Dan St{\ae}rk",
year = "2019",
doi = "10.1016/j.phytochem.2019.112054",
language = "English",
volume = "166",
pages = "1--8",
journal = "Phytochemistry",
issn = "0031-9422",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - 2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora

T2 - High-resolution inhibition profiling and PTP1B inhibitory activity

AU - Zhao, Yong

AU - Kjaerulff, Louise

AU - Kongstad, Kenneth Thermann

AU - Heskes, Allison Maree

AU - Møller, Birger Lindberg

AU - Stærk, Dan

PY - 2019

Y1 - 2019

N2 - Eremophila bignoniiflora is a shrub distributed throughout inland northern and eastern Australia, and it has been used in several medicinal applications by some Australian Aboriginal people. In our continued search for anti-diabetic constituents from natural resources, the crude ethyl acetate extract of E. bignoniiflora was found to have protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 23.9 ± 1.9 μg/mL. High-resolution PTP1B inhibition profiling combined with HRMS and NMR were subsequently used to investigate the individual compounds responsible for the observed bioactivity of the crude extract. This led to identification of five undescribed 2(5H)-furanone sesquiterpenes, together with 13 flavonoids and phenolic compounds. Dose-response curves of the isolated compounds revealed that two 2(5H)-furanone sesquiterpene cinnamates and three flavonoids exhibited moderate PTP1B inhibitory activity with IC50 values from 41.4 ± 1.4 to 154.5 ± 8.9 μM.

AB - Eremophila bignoniiflora is a shrub distributed throughout inland northern and eastern Australia, and it has been used in several medicinal applications by some Australian Aboriginal people. In our continued search for anti-diabetic constituents from natural resources, the crude ethyl acetate extract of E. bignoniiflora was found to have protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 23.9 ± 1.9 μg/mL. High-resolution PTP1B inhibition profiling combined with HRMS and NMR were subsequently used to investigate the individual compounds responsible for the observed bioactivity of the crude extract. This led to identification of five undescribed 2(5H)-furanone sesquiterpenes, together with 13 flavonoids and phenolic compounds. Dose-response curves of the isolated compounds revealed that two 2(5H)-furanone sesquiterpene cinnamates and three flavonoids exhibited moderate PTP1B inhibitory activity with IC50 values from 41.4 ± 1.4 to 154.5 ± 8.9 μM.

U2 - 10.1016/j.phytochem.2019.112054

DO - 10.1016/j.phytochem.2019.112054

M3 - Journal article

C2 - 31284174

VL - 166

SP - 1

EP - 8

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

M1 - 112054

ER -

ID: 217384706