Karel Miettinen

Karel Miettinen

Assistant Professor

Member of:

    ORCID: 0000-0003-2496-8924

    Publication year:
    All
    1 - 16 out of 16Page size: 50
    1. 2013

    2. Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma

      Simkin, A. J., Miettinen, Karel, Claudel, P., Burlat, V., Guirimand, G., Courdavault, V., Papon, N., Meyer, S., Godet, S., St-Pierre, B., Giglioli-Guivarc'H, N., Fischer, M. J. C., Memelink, J. & Clastre, M., 2013, In: Phytochemistry. 85, p. 36-43 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization

      Dong, L., Miettinen, Karel, Goedbloed, M., Verstappen, F. W. A., Voster, A., Jongsma, M. A., Memelink, J., Krol, S. V. D. & Bouwmeester, H. J., 2013, In: Metabolic Engineering. 20, p. 198-211 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2014

    5. The seco-iridoid pathway from Catharanthus roseus

      Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. 2015

    7. Iridoid synthase activity is common among the plant progesterone 5β-reductase family

      Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, Karel, Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2016

    10. The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Gariboldi, I., Espoz, J., Purnama, P. C., Schweizer, F., Miettinen, Karel, Vanden Bossche, R., De Clercq, R., Memelink, J. & Goossens, A., 2016, In: Plant Journal. 88, 1, p. 3-12 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. 2017

    12. A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

      Reed, J., Stephenson, M. J., Miettinen, Karel, Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

      Arendt, P., Miettinen, Karel, Pollier, J., De Rycke, R., Callewaert, N. & Goossens, A., 2017, In: Metabolic Engineering. 40, p. 165-175 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

      Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2018

    16. Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol

      Saiman, M. Z., Miettinen, Karel, Mustafa, N. R., Choi, Y. H., Verpoorte, R. & Schulte, A. E., 2018, In: Plant Cell, Tissue and Organ Culture. 134, 1, p. 41-53 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis

      Miettinen, Karel, Inigo, S., Kreft, L., Pollier, J., De Bo, C., Botzki, A., Coppens, F., Bak, Søren & Goossens, A., 2018, In: Nucleic Acids Research. 46, D1, p. D586-D594 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. 2019

    19. Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins

      Tzin, V., Snyder, J. H., Yang, D. S., Huhman, D. V., Watson, B. S., Allen, S. N., Tang, Y., Miettinen, Karel, Arendt, P., Pollier, J., Goossens, A. & Sumner, L. W., 2019, In: Metabolomics. 15, 6, 85.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. 2020
    21. Published

      Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

      Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. 2022
    23. Published

      A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

      Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

      Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. 2023
    26. Published

      Biosynthesis and biotechnological production of the anti-obesity agent celastrol

      Zhao, Yong, Hansen, N. L., Duan, Yaotao, Prasad, M., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Pateraki, Irini, Stærk, Dan, Bak, Søren, Miettinen, Karel & Kampranis, Sotirios, 2023, In: Nature Chemistry. 15, p. 1236–1246

      Research output: Contribution to journal › Journal article › Research › peer-review

    ID: 194204863