Karel Miettinen

Karel Miettinen

Assistant Professor

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    ORCID: 0000-0003-2496-8924

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    1. The seco-iridoid pathway from Catharanthus roseus

      Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Gariboldi, I., Espoz, J., Purnama, P. C., Schweizer, F., Miettinen, Karel, Vanden Bossche, R., De Clercq, R., Memelink, J. & Goossens, A., 2016, In: Plant Journal. 88, 1, p. 3-12 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, Karel, Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

      Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis

      Miettinen, Karel, Inigo, S., Kreft, L., Pollier, J., De Bo, C., Botzki, A., Coppens, F., Bak, Søren & Goossens, A., 2018, In: Nucleic Acids Research. 46, D1, p. D586-D594 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol

      Saiman, M. Z., Miettinen, Karel, Mustafa, N. R., Choi, Y. H., Verpoorte, R. & Schulte, A. E., 2018, In: Plant Cell, Tissue and Organ Culture. 134, 1, p. 41-53 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Iridoid synthase activity is common among the plant progesterone 5β-reductase family

      Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

      Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins

      Tzin, V., Snyder, J. H., Yang, D. S., Huhman, D. V., Watson, B. S., Allen, S. N., Tang, Y., Miettinen, Karel, Arendt, P., Pollier, J., Goossens, A. & Sumner, L. W., 2019, In: Metabolomics. 15, 6, 85.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

      Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 194204863