Karel Miettinen

Karel Miettinen

Assistant Professor

Member of:


    1. 2013
    2. Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma

      Simkin, A. J., Miettinen, Karel, Claudel, P., Burlat, V., Guirimand, G., Courdavault, V., Papon, N., Meyer, S., Godet, S., St-Pierre, B., Giglioli-Guivarc'H, N., Fischer, M. J. C., Memelink, J. & Clastre, M., 2013, In: Phytochemistry. 85, p. 36-43 8 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    3. Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization

      Dong, L., Miettinen, Karel, Goedbloed, M., Verstappen, F. W. A., Voster, A., Jongsma, M. A., Memelink, J., Krol, S. V. D. & Bouwmeester, H. J., 2013, In: Metabolic Engineering. 20, p. 198-211 14 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    4. 2014
    5. The seco-iridoid pathway from Catharanthus roseus

      Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.

      Research output: Contribution to journalJournal articleResearchpeer-review

    6. 2015
    7. Iridoid synthase activity is common among the plant progesterone 5β-reductase family

      Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    8. The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, Karel, Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135 6 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    9. 2016
    10. The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus

      Van Moerkercke, A., Steensma, P., Gariboldi, I., Espoz, J., Purnama, P. C., Schweizer, F., Miettinen, Karel, Vanden Bossche, R., De Clercq, R., Memelink, J. & Goossens, A., 2016, In: Plant Journal. 88, 1, p. 3-12 10 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    11. 2017
    12. A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

      Reed, J., Stephenson, M. J., Miettinen, Karel, Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    13. An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

      Arendt, P., Miettinen, Karel, Pollier, J., De Rycke, R., Callewaert, N. & Goossens, A., 2017, In: Metabolic Engineering. 40, p. 165-175 11 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

    14. The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

      Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.

      Research output: Contribution to journalJournal articleResearchpeer-review

    15. 2018
    16. Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol

      Saiman, M. Z., Miettinen, Karel, Mustafa, N. R., Choi, Y. H., Verpoorte, R. & Schulte, A. E., 2018, In: Plant Cell, Tissue and Organ Culture. 134, 1, p. 41-53 13 p.

      Research output: Contribution to journalJournal articleResearchpeer-review

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