Karel Miettinen
Assistant Professor
- 2013
Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma
Simkin, A. J., Miettinen, Karel, Claudel, P., Burlat, V., Guirimand, G., Courdavault, V., Papon, N., Meyer, S., Godet, S., St-Pierre, B., Giglioli-Guivarc'H, N., Fischer, M. J. C., Memelink, J. & Clastre, M., 2013, In: Phytochemistry. 85, p. 36-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization
Dong, L., Miettinen, Karel, Goedbloed, M., Verstappen, F. W. A., Voster, A., Jongsma, M. A., Memelink, J., Krol, S. V. D. & Bouwmeester, H. J., 2013, In: Metabolic Engineering. 20, p. 198-211 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
The seco-iridoid pathway from Catharanthus roseus
Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Iridoid synthase activity is common among the plant progesterone 5β-reductase family
Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, Karel, Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus
Van Moerkercke, A., Steensma, P., Gariboldi, I., Espoz, J., Purnama, P. C., Schweizer, F., Miettinen, Karel, Vanden Bossche, R., De Clercq, R., Memelink, J. & Goossens, A., 2016, In: Plant Journal. 88, 1, p. 3-12 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
Reed, J., Stephenson, M. J., Miettinen, Karel, Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids
Arendt, P., Miettinen, Karel, Pollier, J., De Rycke, R., Callewaert, N. & Goossens, A., 2017, In: Metabolic Engineering. 40, p. 165-175 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis
Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol
Saiman, M. Z., Miettinen, Karel, Mustafa, N. R., Choi, Y. H., Verpoorte, R. & Schulte, A. E., 2018, In: Plant Cell, Tissue and Organ Culture. 134, 1, p. 41-53 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 194204863
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Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
Research output: Contribution to journal › Journal article › Research › peer-review
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136
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The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis
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102
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A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Research output: Contribution to journal › Journal article › Research › peer-review
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