Karel Miettinen

Karel Miettinen

Assistant Professor

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    ORCID: 0000-0003-2496-8924

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    1. An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids

      Arendt, P., Miettinen, Karel, Pollier, J., De Rycke, R., Callewaert, N. & Goossens, A., 2017, In: Metabolic Engineering. 40, p. 165-175 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization

      Dong, L., Miettinen, Karel, Goedbloed, M., Verstappen, F. W. A., Voster, A., Jongsma, M. A., Memelink, J., Krol, S. V. D. & Bouwmeester, H. J., 2013, In: Metabolic Engineering. 20, p. 198-211 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

      Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

      Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. The seco-iridoid pathway from Catharanthus roseus

      Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis

      Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

      Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis

      Miettinen, Karel, Inigo, S., Kreft, L., Pollier, J., De Bo, C., Botzki, A., Coppens, F., Bak, Søren & Goossens, A., 2018, In: Nucleic Acids Research. 46, D1, p. D586-D594 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Iridoid synthase activity is common among the plant progesterone 5β-reductase family

      Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules

      Reed, J., Stephenson, M. J., Miettinen, Karel, Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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    ID: 194204863