Karel Miettinen
Assistant Professor
- 2023
- Published
Biosynthesis and biotechnological production of the anti-obesity agent celastrol
Zhao, Yong, Hansen, N. L., Duan, Yaotao, Prasad, M., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Pateraki, Irini, Stærk, Dan, Bak, Søren, Miettinen, Karel & Kampranis, Sotirios, 2023, In: Nature Chemistry. 15, p. 1236–1246Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks
Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins
Tzin, V., Snyder, J. H., Yang, D. S., Huhman, D. V., Watson, B. S., Allen, S. N., Tang, Y., Miettinen, Karel, Arendt, P., Pollier, J., Goossens, A. & Sumner, L. W., 2019, In: Metabolomics. 15, 6, 85.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
Metabolic alteration of Catharanthus roseus cell suspension cultures overexpressing geraniol synthase in the plastids or cytosol
Saiman, M. Z., Miettinen, Karel, Mustafa, N. R., Choi, Y. H., Verpoorte, R. & Schulte, A. E., 2018, In: Plant Cell, Tissue and Organ Culture. 134, 1, p. 41-53 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis
Miettinen, Karel, Inigo, S., Kreft, L., Pollier, J., De Bo, C., Botzki, A., Coppens, F., Bak, Søren & Goossens, A., 2018, In: Nucleic Acids Research. 46, D1, p. D586-D594 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
A translational synthetic biology platform for rapid access to gram-scale quantities of novel drug-like molecules
Reed, J., Stephenson, M. J., Miettinen, Karel, Brouwer, B., Leveau, A., Brett, P., Goss, R. J. M., Goossens, A., O'Connell, M. A. & Osbourn, A., 2017, In: Metabolic Engineering. 42, p. 185-193 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
An endoplasmic reticulum-engineered yeast platform for overproduction of triterpenoids
Arendt, P., Miettinen, Karel, Pollier, J., De Rycke, R., Callewaert, N. & Goossens, A., 2017, In: Metabolic Engineering. 40, p. 165-175 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The ancient CYP716 family is a major contributor to the diversification of eudicot triterpenoid biosynthesis
Miettinen, Karel, Pollier, J., Buyst, D., Arendt, P., Csuk, R., Sommerwerk, S., Moses, T., Mertens, J., Sonawane, P. D., Pauwels, L., Aharoni, A., Martins, J., Nelson, D. R. & Goossens, A., 2017, In: Nature Communications. 8, 14153.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
The basic helix-loop-helix transcription factor BIS2 is essential for monoterpenoid indole alkaloid production in the medicinal plant Catharanthus roseus
Van Moerkercke, A., Steensma, P., Gariboldi, I., Espoz, J., Purnama, P. C., Schweizer, F., Miettinen, Karel, Vanden Bossche, R., De Clercq, R., Memelink, J. & Goossens, A., 2016, In: Plant Journal. 88, 1, p. 3-12 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Iridoid synthase activity is common among the plant progesterone 5β-reductase family
Munkert, J., Pollier, J., Miettinen, Karel, Van Moerkercke, A., Payne, R., Müller-Uri, F., Burlat, V., O'Connor, S. E., Memelink, J., Kreis, W. & Goossens, A., 2015, In: Molecular Plant. 8, 1, p. 136-152 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
Van Moerkercke, A., Steensma, P., Schweizer, F., Pollier, J., Gariboldi, I., Payne, R., Vanden Bossche, R., Miettinen, Karel, Espoz, J., Purnama, P. C., Kellner, F., Seppänen-Laakso, T., O'Connor, S. E., Rischer, H., Memelink, J. & Goossens, A., 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 26, p. 8130-8135 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
The seco-iridoid pathway from Catharanthus roseus
Miettinen, Karel, Dong, L., Navrot, N., Schneider, T., Burlat, V., Pollier, J., Woittiez, L., Van Der Krol, S., Lugan, R., Ilc, T., Verpoorte, R., Oksman-Caldentey, K. M., Martinoia, E., Bouwmeester, H., Goossens, A., Memelink, J. & Werck-Reichhart, D., 2014, In: Nature Communications. 5, 3606.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Characterization of the plastidial geraniol synthase from Madagascar periwinkle which initiates the monoterpenoid branch of the alkaloid pathway in internal phloem associated parenchyma
Simkin, A. J., Miettinen, Karel, Claudel, P., Burlat, V., Guirimand, G., Courdavault, V., Papon, N., Meyer, S., Godet, S., St-Pierre, B., Giglioli-Guivarc'H, N., Fischer, M. J. C., Memelink, J. & Clastre, M., 2013, In: Phytochemistry. 85, p. 36-43 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Characterization of two geraniol synthases from Valeriana officinalis and Lippia dulcis: Similar activity but difference in subcellular localization
Dong, L., Miettinen, Karel, Goedbloed, M., Verstappen, F. W. A., Voster, A., Jongsma, M. A., Memelink, J., Krol, S. V. D. & Bouwmeester, H. J., 2013, In: Metabolic Engineering. 20, p. 198-211 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 194204863
Most downloads
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161
downloads
Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
137
downloads
The TriForC database: a comprehensive up-to-date resource of plant triterpene biosynthesis
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
106
downloads
A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination
Research output: Contribution to journal › Journal article › Research › peer-review
Published