The mechanism of lipid transport by flippases
We aim at deciphering the mechanism of lipid selection by P4 ATPases through structural and biochemical characterization of plant flippases with high sequence identity but different transport specificities. The project is a common effort between three groups at the University of Copenhagen (Rosa Lopez), Aarhus University (Joseph Lyons) and Ruhr University Bochum (Thomas Günther-Pomorski).
The mechanism by which lipid flippases transport their substrate is unclear. Recent structural studies have shed light on this subject in mammalian cells and yeast. However, most plant P4 ATPases have evolved independently of their yeast and mammalian counterparts, and many of the amino acid residues important for lipid recognition are not conserved in plants. Do plant P4 ATPases recognize lipids in the same way as flippases from other organisms?
Researchers
| Name | Title | Phone | |
|---|---|---|---|
| Search in Name | Search in Title | Search in Phone | |
| Rosa Laura Lopez Marques | Professor | +4535332602 |
Funded by:
Project number: 1026-00024B
Period: 1/11/2021 - 31/10/2025
Contact
Rosa Laura López Marqués
Mail: rlo@plen.ku.dk
Phone: +4535332602