Isolation of a substance activating foot formation in hydra

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Standard

Isolation of a substance activating foot formation in hydra. / Grimmelikhuijzen, C J; Schaller, H C.

In: Results and Problems in Cell Differentiation, Vol. 6, No. 5-6, 01.12.1977, p. 297-305.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Grimmelikhuijzen, CJ & Schaller, HC 1977, 'Isolation of a substance activating foot formation in hydra', Results and Problems in Cell Differentiation, vol. 6, no. 5-6, pp. 297-305.

APA

Grimmelikhuijzen, C. J., & Schaller, H. C. (1977). Isolation of a substance activating foot formation in hydra. Results and Problems in Cell Differentiation, 6(5-6), 297-305.

Vancouver

Grimmelikhuijzen CJ, Schaller HC. Isolation of a substance activating foot formation in hydra. Results and Problems in Cell Differentiation. 1977 Dec 1;6(5-6):297-305.

Author

Grimmelikhuijzen, C J ; Schaller, H C. / Isolation of a substance activating foot formation in hydra. In: Results and Problems in Cell Differentiation. 1977 ; Vol. 6, No. 5-6. pp. 297-305.

Bibtex

@article{277cf157a33e448e824b5521efa90440,
title = "Isolation of a substance activating foot formation in hydra",
abstract = "We have developed an assay for a substance from hydra that accelerates foot regeneration in the animal. This substance is specific for the foot as evidenced by the following findings: (1) It is present in the animal as a steep gradient descending from foot to head, paralleling the foot-forming potential of the tissue (2) It does not accelerate head regeneration, nor do the head factors of hydra discovered by Schaller (1973) and Berking (1977) accelerate foot regeneration. We propose that the foot-activating substance is a morphogen responsible for foot formation in hydra. The foot activator can be extracted from hydra tissue with methanol and separated from other known morphogens of hydra by gel filtration and ion-exchange chromatography. A substance with similar biological and physicochemical properties can be isolated from sea anemones.",
keywords = "Animals, Dose-Response Relationship, Drug, Growth Substances, Hydra, Morphogenesis, Regeneration",
author = "Grimmelikhuijzen, {C J} and Schaller, {H C}",
year = "1977",
month = dec,
day = "1",
language = "English",
volume = "6",
pages = "297--305",
journal = "Results and Problems in Cell Differentiation",
issn = "0080-1844",
publisher = "Springer",
number = "5-6",

}

RIS

TY - JOUR

T1 - Isolation of a substance activating foot formation in hydra

AU - Grimmelikhuijzen, C J

AU - Schaller, H C

PY - 1977/12/1

Y1 - 1977/12/1

N2 - We have developed an assay for a substance from hydra that accelerates foot regeneration in the animal. This substance is specific for the foot as evidenced by the following findings: (1) It is present in the animal as a steep gradient descending from foot to head, paralleling the foot-forming potential of the tissue (2) It does not accelerate head regeneration, nor do the head factors of hydra discovered by Schaller (1973) and Berking (1977) accelerate foot regeneration. We propose that the foot-activating substance is a morphogen responsible for foot formation in hydra. The foot activator can be extracted from hydra tissue with methanol and separated from other known morphogens of hydra by gel filtration and ion-exchange chromatography. A substance with similar biological and physicochemical properties can be isolated from sea anemones.

AB - We have developed an assay for a substance from hydra that accelerates foot regeneration in the animal. This substance is specific for the foot as evidenced by the following findings: (1) It is present in the animal as a steep gradient descending from foot to head, paralleling the foot-forming potential of the tissue (2) It does not accelerate head regeneration, nor do the head factors of hydra discovered by Schaller (1973) and Berking (1977) accelerate foot regeneration. We propose that the foot-activating substance is a morphogen responsible for foot formation in hydra. The foot activator can be extracted from hydra tissue with methanol and separated from other known morphogens of hydra by gel filtration and ion-exchange chromatography. A substance with similar biological and physicochemical properties can be isolated from sea anemones.

KW - Animals

KW - Dose-Response Relationship, Drug

KW - Growth Substances

KW - Hydra

KW - Morphogenesis

KW - Regeneration

M3 - Journal article

C2 - 597869

VL - 6

SP - 297

EP - 305

JO - Results and Problems in Cell Differentiation

JF - Results and Problems in Cell Differentiation

SN - 0080-1844

IS - 5-6

ER -

ID: 33515022