Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates
Research output: Contribution to journal › Journal article › Research › peer-review
Mitochondrial proteostasis is essential for survival, and imbalances can result in severe human diseases. We identified a novel stress response triggered upon accumulation of proteotoxic aggregates in the mitochondrial matrix. Mitochondria-to-nucleus signaling results in a transcriptional response and translocation of a nuclear transcription factor into mitochondria to maintain mitochondrial gene expression.
Original language | English |
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Article number | 1698256 |
Journal | Molecular & Cellular Oncology |
Volume | 7 |
Issue number | 1 |
ISSN | 2372-3556 |
DOIs | |
Publication status | Published - 2020 |
Externally published | Yes |
Bibliographical note
© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
ID: 391634591