Using networks to identify and interpret natural variation
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Using networks to identify and interpret natural variation. / Kliebenstein, Daniel J.
In: Current Opinion in Plant Biology, Vol. 54, 2020, p. 122-126.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Using networks to identify and interpret natural variation
AU - Kliebenstein, Daniel J.
PY - 2020
Y1 - 2020
N2 - Studies on natural variation and network biology inherently work to summarize vast amounts of information and data. The combination of these two areas of study while creating datasets of immense complexity is critical to their mutual progress. Networks are necessary as a way to work to reduce the dimensionality inherent in natural variation with 100 s to 1000 s of genotypes. Correspondingly natural variation is essential for testing how networks may or may not be shared across individuals or species. Advances in this area of cross-fertilization including using networks directly as phenotypes and the use of networks to help in prioritizing candidate gene validation efforts. Interesting new observations on frequent presence-absence variation in gene content and adaptation is beginning to highlight the potential for natural variation in network presence-absence. This review attempts to delve into these new insights.
AB - Studies on natural variation and network biology inherently work to summarize vast amounts of information and data. The combination of these two areas of study while creating datasets of immense complexity is critical to their mutual progress. Networks are necessary as a way to work to reduce the dimensionality inherent in natural variation with 100 s to 1000 s of genotypes. Correspondingly natural variation is essential for testing how networks may or may not be shared across individuals or species. Advances in this area of cross-fertilization including using networks directly as phenotypes and the use of networks to help in prioritizing candidate gene validation efforts. Interesting new observations on frequent presence-absence variation in gene content and adaptation is beginning to highlight the potential for natural variation in network presence-absence. This review attempts to delve into these new insights.
KW - ARABIDOPSIS
KW - GENES
KW - TRANSCRIPTOME
KW - ACCESSIONS
KW - RESISTANCE
KW - PHENOMICS
U2 - 10.1016/j.pbi.2020.04.005
DO - 10.1016/j.pbi.2020.04.005
M3 - Review
C2 - 32413801
VL - 54
SP - 122
EP - 126
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
SN - 1369-5266
ER -
ID: 249479834