Epistasis × environment interactions among Arabidopsis thaliana glucosinolate genes impact complex traits and fitness in the field
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Epistasis × environment interactions among Arabidopsis thaliana glucosinolate genes impact complex traits and fitness in the field. / Kerwin, Rachel E.; Feusier, Julie; Muok, Alise; Lin, Catherine; Larson, Brandon; Copeland, Daniel; Corwin, Jason A.; Rubin, Matthew J; Francisco, Marta; Li, Baohua; Joseph, Bindu; Weinig, Cynthia; Kliebenstein, Daniel James.
In: New Phytologist, Vol. 215, No. 3, 2017, p. 1249-1263.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Epistasis × environment interactions among Arabidopsis thaliana glucosinolate genes impact complex traits and fitness in the field
AU - Kerwin, Rachel E.
AU - Feusier, Julie
AU - Muok, Alise
AU - Lin, Catherine
AU - Larson, Brandon
AU - Copeland, Daniel
AU - Corwin, Jason A.
AU - Rubin, Matthew J
AU - Francisco, Marta
AU - Li, Baohua
AU - Joseph, Bindu
AU - Weinig, Cynthia
AU - Kliebenstein, Daniel James
N1 - © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.
PY - 2017
Y1 - 2017
N2 - Despite the growing number of studies showing that genotype × environment and epistatic interactions control fitness, the influences of epistasis × environment interactions on adaptive trait evolution remain largely uncharacterized. Across three field trials, we quantified aliphatic glucosinolate (GSL) defense chemistry, leaf damage, and relative fitness using mutant lines of Arabidopsis thaliana varying at pairs of causal aliphatic GSL defense genes to test the impact of epistatic and epistasis × environment interactions on adaptive trait variation. We found that aliphatic GSL accumulation was primarily influenced by additive and epistatic genetic variation, leaf damage was primarily influenced by environmental variation and relative fitness was primarily influenced by epistasis and epistasis × environment interactions. Epistasis × environment interactions accounted for up to 48% of the relative fitness variation in the field. At a single field site, the impact of epistasis on relative fitness varied significantly over 2 yr, showing that epistasis × environment interactions within a location can be temporally dynamic. These results suggest that the environmental dependency of epistasis can profoundly influence the response to selection, shaping the adaptive trajectories of natural populations in complex ways, and deserves further consideration in future evolutionary studies.
AB - Despite the growing number of studies showing that genotype × environment and epistatic interactions control fitness, the influences of epistasis × environment interactions on adaptive trait evolution remain largely uncharacterized. Across three field trials, we quantified aliphatic glucosinolate (GSL) defense chemistry, leaf damage, and relative fitness using mutant lines of Arabidopsis thaliana varying at pairs of causal aliphatic GSL defense genes to test the impact of epistatic and epistasis × environment interactions on adaptive trait variation. We found that aliphatic GSL accumulation was primarily influenced by additive and epistatic genetic variation, leaf damage was primarily influenced by environmental variation and relative fitness was primarily influenced by epistasis and epistasis × environment interactions. Epistasis × environment interactions accounted for up to 48% of the relative fitness variation in the field. At a single field site, the impact of epistasis on relative fitness varied significantly over 2 yr, showing that epistasis × environment interactions within a location can be temporally dynamic. These results suggest that the environmental dependency of epistasis can profoundly influence the response to selection, shaping the adaptive trajectories of natural populations in complex ways, and deserves further consideration in future evolutionary studies.
KW - Journal Article
U2 - 10.1111/nph.14646
DO - 10.1111/nph.14646
M3 - Journal article
C2 - 28608555
VL - 215
SP - 1249
EP - 1263
JO - New Phytologist
JF - New Phytologist
SN - 0028-646X
IS - 3
ER -
ID: 180939087