Phytohormone Transport

We discover and study transporters to improve biological processes

We characterize transporters in the Xenopus oocyte model system and combine electrophysiology with LCMS transport assays to determine substrate specificities, kinetics, mechanism and stoichiometry. The knowledge gained, guides phenotypical analyses and localization studies in vivo to determine physiological roles and discover exciting applications.

 

 

 

 

 

Human Frontier Science Program , 2020 - June 2024 (10 mill. DKK) A funding program that supports pioneering international research projects which investigate complex mechanisms in living organism. Phytohormone transport in plants – Using a combination of functional and phenotypic screens we seek to unravel the phytohormone transportome in plants and characterize physiological roles.

Novocrops: Accelerated domestication of resilient climate-change friendly plant species - 2020 - 2025 (5,6 mill DKK)
Identification of transporters of antinutritional plant natural compounds in 3 crops to allow tissue specific removal without compromising plant fitness

Ascending Investigator, Novo Nordisk Foundation,  1 Sept. 2023 - 31 Aug. 2028  (10 mill. DKK). TRANSFORM - Unleashing the transformative potential of transport engineering in crop improvement.

Exploratory interdisciplinary synergy grant on Leveraging plant transportomics, Novo Nordisk Foundation,  January 2024 – Dec. 2026 (4 mill. DKK)
Identifying ABCC6 transporter substrate preventing vascular calcification.

Establishing method for deorphanizing the ABCC6 transporter, which is the only causative gene associated with PXE - a rare genetic disease leading to calcification of elastic fibers.

Breaking the yield barrier in microalgae cultivation -  Novo Nordisk Foundation, January 2024 – Dec. 2026 (3 mill DKK)
Using C.reihardtii as a case study, we seek to establish heterotrophic growth on external sources of glucose and understand why many microalgae are not able to grow on external sugar.

Carlsberg foundation infrastructure,  2023 (300.000 DKK)

Understanding molecular determinants of substrate specificity in the NPF – using the three glucosinolate transporters (GTR1-3) as model system we use bioinformatics and mutational analyses to understand the molecular basis for distinct substrate preferences.

 

 

 

 

 

Group members

Name Title Phone E-mail
Antonina Atanasova Karakostova Postdoc +4535337300 E-mail
Caroline Marcher Holm PhD Fellow E-mail
Christa Kanstrup Postdoc +4535336738 E-mail
Eva Højgaard Jensen Laboratory Assistant +4535331476 E-mail
Harsh Yadav PhD Fellow +4535326122 E-mail
Louise Svenningsen Laboratory Technician +4535332358 E-mail
Victor de Prado Parralejo PhD Fellow +4535323718 E-mail
Zeinu Mussa Belew Research Assistant +4591432290 E-mail

Master students

  • Jonathan Karlog, MSc student

  • Melanie Peters Funch, MSc student

Hussam Hassan Nour-Eldin

Research Group Leader

Hussam Hassan Nour-Eldin
huha@plen.ku.dk
+45 35 33 36 98