The P450 genes of the cat flea, Ctenocephalides felis: a CYPome in flux
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The P450 genes of the cat flea, Ctenocephalides felis : a CYPome in flux. / Feyereisen, René.
In: Current Research in Insect Science, Vol. 2, 100032, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The P450 genes of the cat flea, Ctenocephalides felis
T2 - a CYPome in flux
AU - Feyereisen, René
N1 - Publisher Copyright: © 2022
PY - 2022
Y1 - 2022
N2 - The genome of the cat flea, an ectoparasite of major veterinary importance and the first representative of the Siphonaptera, is highly unusual among arthropod genomes in showing a variable size and a very large number of gene duplications (Driscoll et al., 2020). The cat flea is the target of several classes of insecticides, justifying the description of its CYPome, the complement of P450s that are an important family of detoxification enzymes. 103 P450 genes were annotated on the nine chromosomes, with an additional 12 genes on small, extrachromosomal scaffolds. Only 34 genes were found as single sequences, with 47 duplicated two to four-fold. This included duplication of genes that are mostly single copy P450 genes in other arthropods. Large clusters of mitochondrial clan P450s were observed, resulting in a CYP12 bloom within this clan to 34 genes, a number of mitochondrial P450s not seen in other animals so far. The variable geometry of the cat flea CYPome poses a challenge to the study of P450 function in this species, and raises the question of the underlying causes of single copy control versus multicopy licence of P450 genes.
AB - The genome of the cat flea, an ectoparasite of major veterinary importance and the first representative of the Siphonaptera, is highly unusual among arthropod genomes in showing a variable size and a very large number of gene duplications (Driscoll et al., 2020). The cat flea is the target of several classes of insecticides, justifying the description of its CYPome, the complement of P450s that are an important family of detoxification enzymes. 103 P450 genes were annotated on the nine chromosomes, with an additional 12 genes on small, extrachromosomal scaffolds. Only 34 genes were found as single sequences, with 47 duplicated two to four-fold. This included duplication of genes that are mostly single copy P450 genes in other arthropods. Large clusters of mitochondrial clan P450s were observed, resulting in a CYP12 bloom within this clan to 34 genes, a number of mitochondrial P450s not seen in other animals so far. The variable geometry of the cat flea CYPome poses a challenge to the study of P450 function in this species, and raises the question of the underlying causes of single copy control versus multicopy licence of P450 genes.
KW - cat flea
KW - gene duplication
KW - mitochondrial P450
KW - Siphonaptera
U2 - 10.1016/j.cris.2022.100032
DO - 10.1016/j.cris.2022.100032
M3 - Journal article
C2 - 36003260
AN - SCOPUS:85125679028
VL - 2
JO - Current Research in Insect Science
JF - Current Research in Insect Science
SN - 2666-5158
M1 - 100032
ER -
ID: 342967790