The ease and complexity of identifying and using specialized metabolites for crop engineering

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The ease and complexity of identifying and using specialized metabolites for crop engineering. / Muhich, Anna Jo; Agosto-Ramos, Amanda; Kliebenstein, Daniel J.

In: Emerging topics in life sciences, Vol. 6, 2022, p. 153-162.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Muhich, AJ, Agosto-Ramos, A & Kliebenstein, DJ 2022, 'The ease and complexity of identifying and using specialized metabolites for crop engineering', Emerging topics in life sciences, vol. 6, pp. 153-162. https://doi.org/10.1042/ETLS20210248

APA

Muhich, A. J., Agosto-Ramos, A., & Kliebenstein, D. J. (2022). The ease and complexity of identifying and using specialized metabolites for crop engineering. Emerging topics in life sciences, 6, 153-162. https://doi.org/10.1042/ETLS20210248

Vancouver

Muhich AJ, Agosto-Ramos A, Kliebenstein DJ. The ease and complexity of identifying and using specialized metabolites for crop engineering. Emerging topics in life sciences. 2022;6:153-162. https://doi.org/10.1042/ETLS20210248

Author

Muhich, Anna Jo ; Agosto-Ramos, Amanda ; Kliebenstein, Daniel J. / The ease and complexity of identifying and using specialized metabolites for crop engineering. In: Emerging topics in life sciences. 2022 ; Vol. 6. pp. 153-162.

Bibtex

@article{22d2108b8bb24e14a24f469570a3a7b2,
title = "The ease and complexity of identifying and using specialized metabolites for crop engineering",
abstract = "Plants produce a broad variety of specialized metabolites with distinct biological activities and potential applications. Despite this potential, most biosynthetic pathways governing specialized metabolite production remain largely unresolved across the plant kingdom. The rapid advancement of genetics and biochemical tools has enhanced our ability to identify plant specialized metabolic pathways. Further advancements in transgenic technology and synthetic biology approaches have extended this to a desire to design new pathways or move existing pathways into new systems to address long-running difficulties in crop systems. This includes improving abiotic and biotic stress resistance, boosting nutritional content, etc. In this review, we assess the potential and limitations for (1) identifying specialized metabolic pathways in plants with multi-omics tools and (2) using these enzymes in synthetic biology or crop engineering. The goal of these topics is to highlight areas of research that may need further investment to enhance the successful application of synthetic biology for exploiting the myriad of specialized metabolic pathways.",
keywords = "GLUCOSINOLATE BIOSYNTHESIS, APHID RESISTANCE, ARABIDOPSIS, METABOLOMICS, EVOLUTION, PATHWAY, ENZYMES, IDENTIFICATION, ACCUMULATION, DIVERSITY",
author = "Muhich, {Anna Jo} and Amanda Agosto-Ramos and Kliebenstein, {Daniel J.}",
year = "2022",
doi = "10.1042/ETLS20210248",
language = "English",
volume = "6",
pages = "153--162",
journal = "Emerging topics in life sciences",
issn = "2397-8554",
publisher = "Portland Press, Ltd.",

}

RIS

TY - JOUR

T1 - The ease and complexity of identifying and using specialized metabolites for crop engineering

AU - Muhich, Anna Jo

AU - Agosto-Ramos, Amanda

AU - Kliebenstein, Daniel J.

PY - 2022

Y1 - 2022

N2 - Plants produce a broad variety of specialized metabolites with distinct biological activities and potential applications. Despite this potential, most biosynthetic pathways governing specialized metabolite production remain largely unresolved across the plant kingdom. The rapid advancement of genetics and biochemical tools has enhanced our ability to identify plant specialized metabolic pathways. Further advancements in transgenic technology and synthetic biology approaches have extended this to a desire to design new pathways or move existing pathways into new systems to address long-running difficulties in crop systems. This includes improving abiotic and biotic stress resistance, boosting nutritional content, etc. In this review, we assess the potential and limitations for (1) identifying specialized metabolic pathways in plants with multi-omics tools and (2) using these enzymes in synthetic biology or crop engineering. The goal of these topics is to highlight areas of research that may need further investment to enhance the successful application of synthetic biology for exploiting the myriad of specialized metabolic pathways.

AB - Plants produce a broad variety of specialized metabolites with distinct biological activities and potential applications. Despite this potential, most biosynthetic pathways governing specialized metabolite production remain largely unresolved across the plant kingdom. The rapid advancement of genetics and biochemical tools has enhanced our ability to identify plant specialized metabolic pathways. Further advancements in transgenic technology and synthetic biology approaches have extended this to a desire to design new pathways or move existing pathways into new systems to address long-running difficulties in crop systems. This includes improving abiotic and biotic stress resistance, boosting nutritional content, etc. In this review, we assess the potential and limitations for (1) identifying specialized metabolic pathways in plants with multi-omics tools and (2) using these enzymes in synthetic biology or crop engineering. The goal of these topics is to highlight areas of research that may need further investment to enhance the successful application of synthetic biology for exploiting the myriad of specialized metabolic pathways.

KW - GLUCOSINOLATE BIOSYNTHESIS

KW - APHID RESISTANCE

KW - ARABIDOPSIS

KW - METABOLOMICS

KW - EVOLUTION

KW - PATHWAY

KW - ENZYMES

KW - IDENTIFICATION

KW - ACCUMULATION

KW - DIVERSITY

U2 - 10.1042/ETLS20210248

DO - 10.1042/ETLS20210248

M3 - Review

C2 - 35302160

VL - 6

SP - 153

EP - 162

JO - Emerging topics in life sciences

JF - Emerging topics in life sciences

SN - 2397-8554

ER -

ID: 302198526