Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine
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Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine. / Kesten, Christopher; Leitner, Valentin; Dora, Susanne; Sims, James W.; Dindas, Julian; Zipfel, Cyril; De Moraes, Consuelo M.; Sanchez-Rodriguez, Clara.
In: eLife, Vol. 12, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Soil-borne fungi alter the apoplastic purinergic signaling in plants by deregulating the homeostasis of extracellular ATP and its metabolite adenosine
AU - Kesten, Christopher
AU - Leitner, Valentin
AU - Dora, Susanne
AU - Sims, James W.
AU - Dindas, Julian
AU - Zipfel, Cyril
AU - De Moraes, Consuelo M.
AU - Sanchez-Rodriguez, Clara
N1 - Publisher Copyright: © 2023, Kesten, Leitner et al.
PY - 2023
Y1 - 2023
N2 - Purinergic signaling activated by extracellular nucleotides and their derivative nucleosides trigger sophisticated signaling networks. The outcome of these pathways determine the capacity of the organism to survive under challenging conditions. Both extracellular ATP (eATP) and Adenosine (eAdo) act as primary messengers in mammals, essential for immunosuppressive responses. Despite the clear role of eATP as a plant damage-associated molecular pattern, the function of its nucleoside, eAdo, and of the eAdo/eATP balance in plant stress response remain to be fully elucidated. This is particularly relevant in the context of plant-microbe interaction, where the intruder manipulates the extracellular matrix. Here, we identify Ado as a main molecule secreted by the vascular fungus Fusarium oxysporum. We show that eAdo modulates the plant's susceptibility to fungal colonization by altering the eATP-mediated apoplastic pH homeostasis, an essential physiological player during the infection of this pathogen. Our work indicates that plant pathogens actively imbalance the apoplastic eAdo/eATP levels as a virulence mechanism.
AB - Purinergic signaling activated by extracellular nucleotides and their derivative nucleosides trigger sophisticated signaling networks. The outcome of these pathways determine the capacity of the organism to survive under challenging conditions. Both extracellular ATP (eATP) and Adenosine (eAdo) act as primary messengers in mammals, essential for immunosuppressive responses. Despite the clear role of eATP as a plant damage-associated molecular pattern, the function of its nucleoside, eAdo, and of the eAdo/eATP balance in plant stress response remain to be fully elucidated. This is particularly relevant in the context of plant-microbe interaction, where the intruder manipulates the extracellular matrix. Here, we identify Ado as a main molecule secreted by the vascular fungus Fusarium oxysporum. We show that eAdo modulates the plant's susceptibility to fungal colonization by altering the eATP-mediated apoplastic pH homeostasis, an essential physiological player during the infection of this pathogen. Our work indicates that plant pathogens actively imbalance the apoplastic eAdo/eATP levels as a virulence mechanism.
KW - A. thaliana
KW - Adenosine
KW - apoplast
KW - Fusarium oxysporum
KW - infectious disease
KW - microbiology
KW - plant biology
U2 - 10.7554/eLife.92913
DO - 10.7554/eLife.92913
M3 - Journal article
C2 - 37994905
AN - SCOPUS:85180768836
VL - 12
JO - eLife
JF - eLife
SN - 2050-084X
ER -
ID: 382551937