Population genomics of ancient and modern Trichuris trichiura
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Population genomics of ancient and modern Trichuris trichiura. / Doyle, Stephen R.; Søe, Martin Jensen; Nejsum, Peter; Betson, Martha; Cooper, Philip J.; Peng, Lifei; Zhu, Xing Quan; Sanchez, Ana; Matamoros, Gabriela; Sandoval, Gustavo Adolfo Fontecha; Cutillas, Cristina; Tchuenté, Louis Albert Tchuem; Mekonnen, Zeleke; Ame, Shaali M.; Namwanje, Harriet; Levecke, Bruno; Berriman, Matthew; Fredensborg, Brian Lund; Kapel, Christian Moliin Outzen.
In: Nature Communications, Vol. 13, No. 1, 3888, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Population genomics of ancient and modern Trichuris trichiura
AU - Doyle, Stephen R.
AU - Søe, Martin Jensen
AU - Nejsum, Peter
AU - Betson, Martha
AU - Cooper, Philip J.
AU - Peng, Lifei
AU - Zhu, Xing Quan
AU - Sanchez, Ana
AU - Matamoros, Gabriela
AU - Sandoval, Gustavo Adolfo Fontecha
AU - Cutillas, Cristina
AU - Tchuenté, Louis Albert Tchuem
AU - Mekonnen, Zeleke
AU - Ame, Shaali M.
AU - Namwanje, Harriet
AU - Levecke, Bruno
AU - Berriman, Matthew
AU - Fredensborg, Brian Lund
AU - Kapel, Christian Moliin Outzen
N1 - Publisher Copyright: © 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.
AB - The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.
U2 - 10.1038/s41467-022-31487-x
DO - 10.1038/s41467-022-31487-x
M3 - Journal article
C2 - 35794092
AN - SCOPUS:85133630658
VL - 13
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 3888
ER -
ID: 314160296