Phage and Quorum Sensing
We transform this knowledge into concrete methods to block bacterial defense mechanisms to develop novel and more effective use of phage therapy and phage based technologies for biocontrol.
- Phage-quorum sensing interactions
- Phage-host interactions
- Blocking phage-defenses
- Phage-mediated stress responses
- The effect of antibiotics on quorum sensing-mediated group behaviors
- Phage engineering for phage therapy and biocontrol
- An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCCmec Cassette
Mikkelsen, K., Bowring, Janine Zara, Ng, Y. K., Svanberg Frisinger, Frida, Maglegaard, J. K., Li, Q., Sieber, R. N., Petersen, A., Andersen, P. S., Rostøl, J. T., Høyland-Kroghsbo, Nina Molin & Ingmer, Hanne, 2023, I: Microbiology Spectrum. 11, 4, e01277-23. - The great divide: rhamnolipids mediate separation between P. aeruginosa and S. aureus
Bru, J., Kasallis, S. J., Chang, R., Zhuo, Q., Nguyen, J., Pham, P., Warren, E., Whiteson, K., Høyland-Kroghsbo, Nina Molin, Limoli, D. H. & Siryaporn, A., 2023, I: Frontiers in Cellular and Infection Microbiology. 13, 16 s., 1245874.
- Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant
Høyland-Kroghsbo, Nina Molin & Bassler, B. L., 2022, I: Journal of Bacteriology. 204, 5, 14 s., e00557-21.
- Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation
Wong, G. C. L., Antani, J. D., Lele, P., Nan, B., Kühn, M. J., Persat, A., Bru, J., Høyland-Kroghsbo, Nina Molin, Siryaporn, A., Conrad, J., Carrara, F., Yawata, Y., Stocker, R., Brun, Y., Whitfield, G., Lee, C., de Anda, J., Schmidt, W. C., Golestanian, R., O'Toole, G. A., Floyd, K., Yildiz, F., Yang, S., Jin, F., Toyofuku, M., Eberl, L., Nobuhiko, N., Zacharoff, L., El-Naggar, M. Y., Yalcin, S. E., Malvankar, N., Rojas-Andrade, M. D., Hochbaum, A., Yan, J., Stone, H. A., Wingreen, N. S., Bassler, B., Wu, Y., Xu, H., Drescher, K. & Dunkel, J., 2021, I: Physical Biology. 18, 5, 50 s. - The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa
Broniewski, J. M., Chisnall, M. A. W., Høyland-Kroghsbo, Nina Molin, Buckling, A. & Westra, E. R., 2021, I: I S M E Journal. 15, s. 2465-2473 - PQS Produced by the Pseudomonas aeruginosa Stress Response Repels Swarms Away from Bacteriophage and Antibiotics
Bru, J., Rawson, B., Trinh, C., Whiteson, K., Høyland-Kroghsbo, Nina Molin & Siryaporn, A., 1 dec. 2019, I: Journal of Bacteriology. 201, 23, e00383-19. - Temperature, by Controlling Growth Rate, Regulates CRISPR-Cas Activity in Pseudomonas aeruginosa
Høyland-Kroghsbo, Nina Molin, Muñoz, K. A. & Bassler, B. L., 13 nov. 2018, I: mBio. 9, 6, 12 s., e02184-18. - Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system
Høyland-Kroghsbo, Nina Molin, Paczkowski, J., Mukherjee, S., Broniewski, J., Westra, E., Bondy-Denomy, J. & Bassler, B. L., 2017, I: National Academy of Sciences. Proceedings. 114, 1, s. 131-135 5 s. - A quorum-sensing-induced bacteriophage defense mechanism
Høyland-Kroghsbo, Nina Molin, Mærkedahl, R. B. & Svenningsen, Sine Lo, 2013, I: mBio. 4, 1, s. 1-9 9 s.
International collaborators:
Jing Yan, Yale University, USA. Jon Paczkowski, Wadsworth Center, New York State Department of Health and School of Public Health, University at Albany, SUNY, USA. Ahlam Alsaadi, PI and founder of the phage therapy unit at King Abdullah International Medical Research Center, Saudi Arabia. Albert Siryaporn, University of California, Irvine, USA. Edze Westra, University of Exeter, UK. Joseph Bondy-Denomy, University of California, San Francisco, USA. Pilar Marco, Spanish National Research Council, Spain.
Collaborators at UCPH:
Jonathan Z. Shik, BIO, and Smithsonian Tropical Research Institute, Republic of Panama. Hanne Ingmer and Andrew Richard Williams, both at the Department of Veterinary and Animal Sciences.
Collaborators at PLEN:
Collaborators on ongoing projects: Rosanna C. Hennessy, Mette H. Nicolaisen, and Lars H. Hansen. Additionally, NMHK has discussed potential new projects with Elizabeth Heather Jakobsen Neilson, Deyang Xu, Rosa Laura Lopez Marques, and Henrik Hjarvard de Fine Licht.
Researchers
| Name | Title | Phone | |
|---|---|---|---|
| Search in Name | Search in Title | Search in Phone | |
| Jesper Juel Mauritzen | Postdoc | ||
| Kira Céline Koonce | PhD Fellow | +4535325439 | |
| Nina Molin Høyland-Kroghsbo | Associate Professor | +4535334292 |
Additional group members
- Ida Friberg Hitz (Master student)
- Bahar Hayta (Master student)
- Amalie Høgh Eichler (Master student)
- Elisabeth Faber (Master student)
- Anna Megumi Karahashi Rasmussen (Master student)
