Phage and Quorum Sensing
Our research explores how bacteria use the cell-cell communication process called quorum sensing (QS) to predict and respond to dangers they encounter in their environment, such as bacteriophage viruses, competing bacteria, and antibiotics.
We transform this knowledge into concrete methods to block bacterial defense mechanisms to develop novel and more effective use of phage therapy and phage based technologies for biocontrol.
- Phage-quorum sensing interactions
- Phage-host interactions
- Blocking phage-defenses
- Phage-mediated stress responses
- The effect of antibiotics on quorum sensing-mediated group behaviors
- Phage engineering for phage therapy and biocontrol
- An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCCmec Cassette
Mikkelsen, K., Bowring, Janine Zara, Ng, Y. K., Svanberg Frisinger, Frida, Maglegaard, J. K., Li, Q., Sieber, R. N., Petersen, A., Andersen, P. S., Rostøl, J. T., Høyland-Kroghsbo, Nina Molin & Ingmer, Hanne, 2023, I: Microbiology Spectrum. 11, 4, e01277-23. - The great divide: rhamnolipids mediate separation between P. aeruginosa and S. aureus
Bru, J., Kasallis, S. J., Chang, R., Zhuo, Q., Nguyen, J., Pham, P., Warren, E., Whiteson, K., Høyland-Kroghsbo, Nina Molin, Limoli, D. H. & Siryaporn, A., 2023, I: Frontiers in Cellular and Infection Microbiology. 13, 16 s., 1245874.
- Phage Infection Restores PQS Signaling and Enhances Growth of a Pseudomonas aeruginosa lasI Quorum-Sensing Mutant
Høyland-Kroghsbo, Nina Molin & Bassler, B. L., 2022, I: Journal of Bacteriology. 204, 5, 14 s., e00557-21.
- Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation
Wong, G. C. L., Antani, J. D., Lele, P., Nan, B., Kühn, M. J., Persat, A., Bru, J., Høyland-Kroghsbo, Nina Molin, Siryaporn, A., Conrad, J., Carrara, F., Yawata, Y., Stocker, R., Brun, Y., Whitfield, G., Lee, C., de Anda, J., Schmidt, W. C., Golestanian, R., O'Toole, G. A., Floyd, K., Yildiz, F., Yang, S., Jin, F., Toyofuku, M., Eberl, L., Nobuhiko, N., Zacharoff, L., El-Naggar, M. Y., Yalcin, S. E., Malvankar, N., Rojas-Andrade, M. D., Hochbaum, A., Yan, J., Stone, H. A., Wingreen, N. S., Bassler, B., Wu, Y., Xu, H., Drescher, K. & Dunkel, J., 2021, I: Physical Biology. 18, 5, 50 s. - The effect of Quorum sensing inhibitors on the evolution of CRISPR-based phage immunity in Pseudomonas aeruginosa
Broniewski, J. M., Chisnall, M. A. W., Høyland-Kroghsbo, Nina Molin, Buckling, A. & Westra, E. R., 2021, I: I S M E Journal. 15, s. 2465-2473 - PQS Produced by the Pseudomonas aeruginosa Stress Response Repels Swarms Away from Bacteriophage and Antibiotics
Bru, J., Rawson, B., Trinh, C., Whiteson, K., Høyland-Kroghsbo, Nina Molin & Siryaporn, A., 1 dec. 2019, I: Journal of Bacteriology. 201, 23, e00383-19. - Temperature, by Controlling Growth Rate, Regulates CRISPR-Cas Activity in Pseudomonas aeruginosa
Høyland-Kroghsbo, Nina Molin, Muñoz, K. A. & Bassler, B. L., 13 nov. 2018, I: mBio. 9, 6, 12 s., e02184-18. - Quorum sensing controls the Pseudomonas aeruginosa CRISPR-Cas adaptive immune system
Høyland-Kroghsbo, Nina Molin, Paczkowski, J., Mukherjee, S., Broniewski, J., Westra, E., Bondy-Denomy, J. & Bassler, B. L., 2017, I: National Academy of Sciences. Proceedings. 114, 1, s. 131-135 5 s. - A quorum-sensing-induced bacteriophage defense mechanism
Høyland-Kroghsbo, Nina Molin, Mærkedahl, R. B. & Svenningsen, Sine Lo, 2013, I: mBio. 4, 1, s. 1-9 9 s.
- DFF Sapere Aude: Targeting bacterial defenses for effective therapies - Engineering bacteriophages to circumvent bacterial defenses.
- NNF Global Science Summit (Co-PI) CLIMATE READY SORGHUM - Enhancing BNI potential for sustainable smallholder agriculture.
- NNF Pioneer Innovator: Antibacterial Metabolic hijacking - Engineering bacteriophages to control bacterial metabolism.
- NNF Pioneer Innovator: FortiPhage – Fortifying phages for enhanced antibacterial effect.
- DFF1 (Co-PI) POLYPATH - Unlocking the potential of dietary polyphenols to protect against mucosal pathogen infection.
Researchers
| Name | Title | Phone | |
|---|---|---|---|
| Search in Name | Search in Title | Search in Phone | |
| Ida Friberg Hitz | Research Assistant | +4535335512 | |
| Jesper Juel Mauritzen | Postdoc | ||
| Kira Céline Koonce | PhD Fellow | +4535325439 | |
| Nina Molin Høyland-Kroghsbo | Associate Professor | +4535334292 |
Additional group members
- Eva Oros (technician)
- Amalie Høgh Eichler (Master student)
- Elisabeth Faber (Master student)
- Anna Megumi Karahashi Rasmussen (Master student)
- Amanda Damtoft Frederiksen (Master student)
- Thomas Frank Iversen (Bachelor student)
- Søren Vindvad Gade Holm (Bachelor student)
