Change your Tplate, change your fate: Plant CME and beyond
Research output: Contribution to journal › Review › Research › peer-review
Clathrin-mediated endocytosis (CME) is the predominant and evolutionarily conserved pathway by which eukaryotes internalize cargoes (i.e., plasma membrane proteins, lipids, and extracellular material) that are engaged in a variety of processes. Initiation of CME relies on adaptor proteins, which precisely select the cargoes for internalization, recruit the clathrin cage, and start membrane curvature. The recently identified CME early adaptor complex, the TPLATE complex (TPC), is essential for CME in plants. Phylogenetic analyses suggest that the TPC evolved from an ancient protein complex involved in vesicle trafficking in early eukaryotes, which raises questions about CME evolution and adaptation within the eukaryotic Kingdoms. In this review, we focus on the early events of plant CME and explore evolutionary aspects related to CME in other eukaryotes.
Original language | English |
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Journal | Trends in Plant Science |
Volume | 20 |
Issue number | 1 |
Pages (from-to) | 41-48 |
Number of pages | 8 |
ISSN | 1360-1385 |
DOIs | |
Publication status | Published - 2015 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:
© 2014 Elsevier Ltd.
- AP-2 complex, Clathrin-mediated endocytosis, Eukaryote evolution, Plant adaptor complexes, TPLATE complex
Research areas
ID: 273074542