Analyzing gene coexpression data by an evolutionary model.

Publikation: Bidrag til bog/antologi/rapportKonferencebidrag i proceedingsForskningfagfællebedømt

Coexpressed genes are tentatively translated into proteins that are involved in similar biological functions. Here, we constructed gene coexpression networks from collected microarray data of the organisms Arabidopsis thaliana, Saccharomyces cerevisiae, and Escherichia coli. Their degree distributions show the common property of an overrepresentation of highly connected nodes followed by a sudden truncation. In order to analyze this behavior, we present an evolutionary model simulating the genetic evolution. This model assumes that new genes emerge by duplication from a small initial set of primordial genes. Our model does not include the removal of unused genes but selective pressure is indirectly taken into account by preferentially duplicating the old genes. Thus, gene duplication represents the emergence of a new gene and its successful establishment. After a duplication event, all genes are slightly but iteratively mutated, thus altering their expression patterns. Our model is capable of reproducing global properties of the investigated coexpression networks. We show that our model reflects the mean inter-node distances and especially the characteristic humps in the degree distribution that, in the biological examples, result from functionally related genes.

OriginalsprogEngelsk
TitelGenome Informatics 2010 : Proceedings of the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) , Kyoto University, Japan , 26 – 28 July 2010
RedaktørerTatsuya Akutsu, Minoru Kanehisa, Edda Klipp, Satoru Miyano, Scott Mohr, Thomas Tullius, Iwona Wallach
Antal sider10
ForlagWorld Scientific
Publikationsdato2010
Sider154-163
ISBN (Trykt)978-1-84816-657-8
ISBN (Elektronisk)978-1-908977-85-4
DOI
StatusUdgivet - 2010
Eksternt udgivetJa
BegivenhedAnnual International Workshop on Bioinformatics and Systems Biology - Kyoto University, Kyoto, Japan
Varighed: 26 jul. 201028 jul. 2010
Konferencens nummer: 10

Konference

KonferenceAnnual International Workshop on Bioinformatics and Systems Biology
Nummer10
LokationKyoto University
LandJapan
ByKyoto
Periode26/07/201028/07/2010
NavnGenome Informatics Series
Vol/bind24

ID: 273375670