Analyzing gene coexpression data by an evolutionary model.
Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt
Coexpressed genes are tentatively translated into proteins that are involved in similar biological functions. Here, we constructed gene coexpression networks from collected microarray data of the organisms Arabidopsis thaliana, Saccharomyces cerevisiae, and Escherichia coli. Their degree distributions show the common property of an overrepresentation of highly connected nodes followed by a sudden truncation. In order to analyze this behavior, we present an evolutionary model simulating the genetic evolution. This model assumes that new genes emerge by duplication from a small initial set of primordial genes. Our model does not include the removal of unused genes but selective pressure is indirectly taken into account by preferentially duplicating the old genes. Thus, gene duplication represents the emergence of a new gene and its successful establishment. After a duplication event, all genes are slightly but iteratively mutated, thus altering their expression patterns. Our model is capable of reproducing global properties of the investigated coexpression networks. We show that our model reflects the mean inter-node distances and especially the characteristic humps in the degree distribution that, in the biological examples, result from functionally related genes.
Originalsprog | Engelsk |
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Titel | Genome Informatics 2010 : Proceedings of the 10th Annual International Workshop on Bioinformatics and Systems Biology (IBSB 2010) , Kyoto University, Japan , 26 – 28 July 2010 |
Redaktører | Tatsuya Akutsu, Minoru Kanehisa, Edda Klipp, Satoru Miyano, Scott Mohr, Thomas Tullius, Iwona Wallach |
Antal sider | 10 |
Forlag | World Scientific |
Publikationsdato | 2010 |
Sider | 154-163 |
ISBN (Trykt) | 978-1-84816-657-8 |
ISBN (Elektronisk) | 978-1-908977-85-4 |
DOI | |
Status | Udgivet - 2010 |
Eksternt udgivet | Ja |
Begivenhed | Annual International Workshop on Bioinformatics and Systems Biology - Kyoto University, Kyoto, Japan Varighed: 26 jul. 2010 → 28 jul. 2010 Konferencens nummer: 10 |
Konference
Konference | Annual International Workshop on Bioinformatics and Systems Biology |
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Nummer | 10 |
Lokation | Kyoto University |
Land | Japan |
By | Kyoto |
Periode | 26/07/2010 → 28/07/2010 |
Navn | Genome Informatics Series |
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Vol/bind | 24 |
ID: 273375670