The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study

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The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome : results from a randomised, double-blind, placebo-controlled study. / Madsen, Anna Maria Alcasid; Halkjaer, Sofie Ingdam; Christensen, Alice Højer; Guenther, Stig; Browne, Patrick Denis; Kallemose, Thomas; Hansen, Lars Hestbjerg; Petersen, Andreas Munk.

I: Scandinavian Journal of Gastroenterology, Bind 56, Nr. 7, 2021, s. 761-769.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Madsen, AMA, Halkjaer, SI, Christensen, AH, Guenther, S, Browne, PD, Kallemose, T, Hansen, LH & Petersen, AM 2021, 'The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study', Scandinavian Journal of Gastroenterology, bind 56, nr. 7, s. 761-769. https://doi.org/10.1080/00365521.2021.1915375

APA

Madsen, A. M. A., Halkjaer, S. I., Christensen, A. H., Guenther, S., Browne, P. D., Kallemose, T., Hansen, L. H., & Petersen, A. M. (2021). The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study. Scandinavian Journal of Gastroenterology, 56(7), 761-769. https://doi.org/10.1080/00365521.2021.1915375

Vancouver

Madsen AMA, Halkjaer SI, Christensen AH, Guenther S, Browne PD, Kallemose T o.a. The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study. Scandinavian Journal of Gastroenterology. 2021;56(7):761-769. https://doi.org/10.1080/00365521.2021.1915375

Author

Madsen, Anna Maria Alcasid ; Halkjaer, Sofie Ingdam ; Christensen, Alice Højer ; Guenther, Stig ; Browne, Patrick Denis ; Kallemose, Thomas ; Hansen, Lars Hestbjerg ; Petersen, Andreas Munk. / The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome : results from a randomised, double-blind, placebo-controlled study. I: Scandinavian Journal of Gastroenterology. 2021 ; Bind 56, Nr. 7. s. 761-769.

Bibtex

@article{b0fae5b7cd904dd79330d41780246252,
title = "The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome: results from a randomised, double-blind, placebo-controlled study",
abstract = "Background Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis. Therefore, faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. In this study, we analysed previously unexamined data from our randomised, double-blind, placebo-controlled study (trial registration number NCT02788071). The objective was to evaluate the effect of FMT on abdominal pain, stool frequency, and stool form. Method The study included 52 adult patients with moderate-to-severe IBS assigned randomly to treatment with FMT capsules or placebo capsules (1:1) for 12 days. The patients were followed for a total of six months, during which they kept a daily symptom diary tracking their abdominal pain on a scale from 0-10 and their bowel movements using the Bristol Stool Form Scale (BSFS). Diary data were not collected before treatment start. Results A statistically significant improvement in stool frequency was found in the FMT group from during treatment to post-treatment and 1 month. No statistically significant differences were found between groups at any time during the study for any of abdominal pain, stool frequency, and stool form (as measured by weighted stool score). Conclusion In this analysis of results from a randomised, double-blind, placebo-controlled study, we found no clinically beneficial effect of FMT on abdominal pain, stool frequency, or stool form. However, since the current literature on the potential role of FMT in treating IBS shows conflicting results, further studies are required. To assess treatment efficacy, we recommend future studies to include daily symptom diaries both before and after treatment intervention.",
keywords = "Faecal microbiota transplantation, irritable bowel syndrome, Bristol Stool Form Scale, abdominal pain, stool frequency, IMPACT",
author = "Madsen, {Anna Maria Alcasid} and Halkjaer, {Sofie Ingdam} and Christensen, {Alice H{\o}jer} and Stig Guenther and Browne, {Patrick Denis} and Thomas Kallemose and Hansen, {Lars Hestbjerg} and Petersen, {Andreas Munk}",
year = "2021",
doi = "10.1080/00365521.2021.1915375",
language = "English",
volume = "56",
pages = "761--769",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - The effect of faecal microbiota transplantation on abdominal pain, stool frequency, and stool form in patients with moderate-to-severe irritable bowel syndrome

T2 - results from a randomised, double-blind, placebo-controlled study

AU - Madsen, Anna Maria Alcasid

AU - Halkjaer, Sofie Ingdam

AU - Christensen, Alice Højer

AU - Guenther, Stig

AU - Browne, Patrick Denis

AU - Kallemose, Thomas

AU - Hansen, Lars Hestbjerg

AU - Petersen, Andreas Munk

PY - 2021

Y1 - 2021

N2 - Background Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis. Therefore, faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. In this study, we analysed previously unexamined data from our randomised, double-blind, placebo-controlled study (trial registration number NCT02788071). The objective was to evaluate the effect of FMT on abdominal pain, stool frequency, and stool form. Method The study included 52 adult patients with moderate-to-severe IBS assigned randomly to treatment with FMT capsules or placebo capsules (1:1) for 12 days. The patients were followed for a total of six months, during which they kept a daily symptom diary tracking their abdominal pain on a scale from 0-10 and their bowel movements using the Bristol Stool Form Scale (BSFS). Diary data were not collected before treatment start. Results A statistically significant improvement in stool frequency was found in the FMT group from during treatment to post-treatment and 1 month. No statistically significant differences were found between groups at any time during the study for any of abdominal pain, stool frequency, and stool form (as measured by weighted stool score). Conclusion In this analysis of results from a randomised, double-blind, placebo-controlled study, we found no clinically beneficial effect of FMT on abdominal pain, stool frequency, or stool form. However, since the current literature on the potential role of FMT in treating IBS shows conflicting results, further studies are required. To assess treatment efficacy, we recommend future studies to include daily symptom diaries both before and after treatment intervention.

AB - Background Irritable bowel syndrome (IBS) is associated with intestinal dysbiosis. Therefore, faecal microbiota transplantation (FMT) has been hypothesised to have a positive effect in patients with IBS. In this study, we analysed previously unexamined data from our randomised, double-blind, placebo-controlled study (trial registration number NCT02788071). The objective was to evaluate the effect of FMT on abdominal pain, stool frequency, and stool form. Method The study included 52 adult patients with moderate-to-severe IBS assigned randomly to treatment with FMT capsules or placebo capsules (1:1) for 12 days. The patients were followed for a total of six months, during which they kept a daily symptom diary tracking their abdominal pain on a scale from 0-10 and their bowel movements using the Bristol Stool Form Scale (BSFS). Diary data were not collected before treatment start. Results A statistically significant improvement in stool frequency was found in the FMT group from during treatment to post-treatment and 1 month. No statistically significant differences were found between groups at any time during the study for any of abdominal pain, stool frequency, and stool form (as measured by weighted stool score). Conclusion In this analysis of results from a randomised, double-blind, placebo-controlled study, we found no clinically beneficial effect of FMT on abdominal pain, stool frequency, or stool form. However, since the current literature on the potential role of FMT in treating IBS shows conflicting results, further studies are required. To assess treatment efficacy, we recommend future studies to include daily symptom diaries both before and after treatment intervention.

KW - Faecal microbiota transplantation

KW - irritable bowel syndrome

KW - Bristol Stool Form Scale

KW - abdominal pain

KW - stool frequency

KW - IMPACT

U2 - 10.1080/00365521.2021.1915375

DO - 10.1080/00365521.2021.1915375

M3 - Journal article

C2 - 34000958

VL - 56

SP - 761

EP - 769

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 7

ER -

ID: 269609348