TY - JOUR

T1 - Setting a baseline for global urban virome surveillance in sewage

AU - Nieuwenhuijse, David F.

AU - Oude Munnink, Bas B.

AU - Phan, My V.T.

AU - Hendriksen, Rene S.

AU - Bego, Artan

AU - Rees, Catherine

AU - Neilson, Elizabeth Heather

AU - Coventry, Kris

AU - Collignon, Peter

AU - Allerberger, Franz

AU - Rahube, Teddie O.

AU - Oliveira, Guilherme

AU - Ivanov, Ivan

AU - Sopheak, Thet

AU - Vuthy, Yith

AU - Yost, Christopher K.

AU - Tabo, Djim adjim

AU - Cuadros-Orellana, Sara

AU - Ke, Changwen

AU - Zheng, Huanying

AU - Baisheng, Li

AU - Jiao, Xiaoyang

AU - Donado-Godoy, Pilar

AU - Coulibaly, Kalpy Julien

AU - Hrenovic, Jasna

AU - Jergović, Matijana

AU - Karpíšková, Renáta

AU - Elsborg, Bodil

AU - Legesse, Mengistu

AU - Eguale, Tadesse

AU - Heikinheimo, Annamari

AU - Villacis, Jose Eduardo

AU - Sanneh, Bakary

AU - Malania, Lile

AU - Nitsche, Andreas

AU - Brinkmann, Annika

AU - Saba, Courage Kosi Setsoafia

AU - Kocsis, Bela

AU - Solymosi, Norbert

AU - Thorsteinsdottir, Thorunn R.

AU - Hatha, Abdulla Mohamed

AU - Alebouyeh, Masoud

AU - Morris, Dearbhaile

AU - O’Connor, Louise

AU - Cormican, Martin

AU - Moran-Gilad, Jacob

AU - Battisti, Antonio

AU - Alba, Patricia

AU - Shakenova, Zeinegul

AU - Kiiyukia, Ciira

AU - the Global Sewage Surveillance project consortium

N1 - Publisher Copyright: © 2020, The Author(s).

PY - 2020

Y1 - 2020

N2 - The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.

AB - The rapid development of megacities, and their growing connectedness across the world is becoming a distinct driver for emerging disease outbreaks. Early detection of unusual disease emergence and spread should therefore include such cities as part of risk-based surveillance. A catch-all metagenomic sequencing approach of urban sewage could potentially provide an unbiased insight into the dynamics of viral pathogens circulating in a community irrespective of access to care, a potential which already has been proven for the surveillance of poliovirus. Here, we present a detailed characterization of sewage viromes from a snapshot of 81 high density urban areas across the globe, including in-depth assessment of potential biases, as a proof of concept for catch-all viral pathogen surveillance. We show the ability to detect a wide range of viruses and geographical and seasonal differences for specific viral groups. Our findings offer a cross-sectional baseline for further research in viral surveillance from urban sewage samples and place previous studies in a global perspective.

U2 - 10.1038/s41598-020-69869-0

DO - 10.1038/s41598-020-69869-0

M3 - Journal article

C2 - 32792677

AN - SCOPUS:85089383261

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 13748

ER -