Lyme disease ecology in a changing world: consensus, uncertainty and critical gaps for improving control
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Lyme disease ecology in a changing world : consensus, uncertainty and critical gaps for improving control. / Kilpatrick, A. Marm; Dobson, Andrew D.M.; Levi, Taal; Salkeld, Daniel J.; Swei, Andrea; Ginsberg, Howard S.; Kjemtrup, Anne; Padgett, Kerry A.; Jensen, Per Moestrup; Fish, Durland; Ogden, Nick H.; Diuk-Wasser, Maria A.
I: Philosophical Transactions of the Royal Society B: Biological Sciences, Bind 372, Nr. 1722, 20160117, 2017.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lyme disease ecology in a changing world
T2 - consensus, uncertainty and critical gaps for improving control
AU - Kilpatrick, A. Marm
AU - Dobson, Andrew D.M.
AU - Levi, Taal
AU - Salkeld, Daniel J.
AU - Swei, Andrea
AU - Ginsberg, Howard S.
AU - Kjemtrup, Anne
AU - Padgett, Kerry A.
AU - Jensen, Per Moestrup
AU - Fish, Durland
AU - Ogden, Nick H.
AU - Diuk-Wasser, Maria A.
N1 - © 2017 The Author(s).
PY - 2017
Y1 - 2017
N2 - Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host-vector-borne zoonotic disease.This article is part of the themed issue 'Conservation, biodiversity and infectious disease: scientific evidence and policy implications'.
AB - Lyme disease is the most common tick-borne disease in temperate regions of North America, Europe and Asia, and the number of reported cases has increased in many regions as landscapes have been altered. Although there has been extensive work on the ecology and epidemiology of this disease in both Europe and North America, substantial uncertainty exists about fundamental aspects that determine spatial and temporal variation in both disease risk and human incidence, which hamper effective and efficient prevention and control. Here we describe areas of consensus that can be built on, identify areas of uncertainty and outline research needed to fill these gaps to facilitate predictive models of disease risk and the development of novel disease control strategies. Key areas of uncertainty include: (i) the precise influence of deer abundance on tick abundance, (ii) how tick populations are regulated, (iii) assembly of host communities and tick-feeding patterns across different habitats, (iv) reservoir competence of host species, and (v) pathogenicity for humans of different genotypes of Borrelia burgdorferi Filling these knowledge gaps will improve Lyme disease prevention and control and provide general insights into the drivers and dynamics of this emblematic multi-host-vector-borne zoonotic disease.This article is part of the themed issue 'Conservation, biodiversity and infectious disease: scientific evidence and policy implications'.
KW - Journal Article
KW - Review
U2 - 10.1098/rstb.2016.0117
DO - 10.1098/rstb.2016.0117
M3 - Review
C2 - 28438910
VL - 372
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1722
M1 - 20160117
ER -
ID: 180760697