Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The NADPH-dependent cytochrome P450 reductase (CPR) is a key electron donor to eucaryotic cytochromes P450 (CYPs). CPR shuttles electrons from NADPH through the FAD and FMN-coenzymes into the iron of the prosthetic heme-group of the CYP. In the course of these electron transfer reactions, CPR undergoes large conformational changes. This mini-review discusses the new evidence provided for such conformational changes involving a combination of a "swinging" and "rotating" model and highlights the molecular mechanisms by which formation of these conformations are controlled and thereby enables CPR to serve as an effective electron transferring "nano-machine".
Originalsprog | Engelsk |
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Tidsskrift | Biochimica et Biophysica Acta - Proteins and Proteomics |
Vol/bind | 1814 |
Udgave nummer | 1 |
Sider (fra-til) | 132-138 |
Antal sider | 7 |
ISSN | 1570-9639 |
DOI | |
Status | Udgivet - 2011 |
Bibliografisk note
Cytochrome P450: Structure, biodiversity and potential for application
ID: 32167860